Retinoids and epigenetic silencing in cancer |
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| Authors: | Johanning Gary L Piyathilake Chandrika J |
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| Affiliation: | Department of Nutrition Sciences, The University of Alabama at Birmingham, Birmingham, AL 35294-3360, USA. |
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| Abstract: | An epigenetic event alters the activity of genes without changing their structure. Methylation reactions are important mediators of epigenetic events in cells. Two recent studies have established a mechanistic link between a vitamin A metabolite and epigenetic alterations of its target promoter that could provide insights about the role of vitamin A in cancer prevention. |
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| Keywords: | vitamin A cancer methylation histones |
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