| 雄激素受体异常激活与激素非依赖性前列腺癌的形成机制 |
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| 引用本文： | 陈朝晖,肖传国. 雄激素受体异常激活与激素非依赖性前列腺癌的形成机制[J]. 医学分子生物学杂志, 2004, 1(5): 309-312 |
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| 作者姓名： | 陈朝晖 肖传国 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院泌尿外科,武汉市,430022;华中科技大学同济医学院附属协和医院泌尿外科,武汉市,430022 |
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| 基金项目： | 国家自然科学基金(No.39600146) |
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| 摘 要： | 前列腺癌进展的晚期常转变为激素非依赖性 ,包括雄激素受体拮抗剂在内的多种细胞外因子能够刺激其增殖。雄激素受体基因突变、多种途径引起的异常磷酸化激活和共激活物的调节失控等是激素非依赖性前列腺癌形成的主要促成因素。以雄激素受体为靶标可能成为晚期前列腺癌的有效治疗途径。
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| 关 键 词： | 前列腺癌 雄激素受体 激素非依赖性 |
| 修稿时间： | 2004-02-27 |
Abnormally Activated Androgen Receptor and the Mechanism of Androgen-Independent Prostate Cancer |
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| CHEN Zhaohui,XIAO Chuanguo. Abnormally Activated Androgen Receptor and the Mechanism of Androgen-Independent Prostate Cancer[J]. Journal of Medical Molecular Biology, 2004, 1(5): 309-312 |
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| Authors: | CHEN Zhaohui XIAO Chuanguo |
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| Affiliation: | CHEN Zhaohui,XIAO Chuanguo Department of Urology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China |
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| Abstract: | Most prostate cancers tend to enter androgen-independent proliferation at their advanced stages. Many kinds of extracellular factors can promote this proliferation, including androgen receptor blockers. The mutation of androgen receptor gene, abnormal phosphorylation and abnormal regulation of co-activators contribute to the formation of androgen-independent prostate cancer. Using androgen-receptor as a target may be an effective approach for the treatment of advanced prostate cancers. |
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| Keywords: | prostate cancer androgen receptor androgen-independence |
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