广地龙中促进子宫收缩的成分

本文研究了自广地龙中提出来的一种引湿性、淡黄色針状結晶(含量約0.2%)对平滑肌器官(特别是对子宮)的作用。介紹了該結晶的提取方法。該結晶0.1毫克加入25毫升Locke液中,能使已孕和未孕大鼠或豚鼠离体子宮角紧张度明显升高,0.3毫克可使之呈痙攣收縮状态。按1毫克/公斤給已孕和未孕麻醉家兔靜脉注射后15—30分钟,在位子宮紧张度升高,作用維持1.5—3小时。按8—10毫克/公斤注射,子宮紧张度立卽升高和血压急剧下降到零而死亡。9只慢性子宫瘻家兔靜脉注射(3—6毫克/公斤)或灌胃給药(10—20毫克/公斤)后15—45分钟,子宮收縮明显增强,作用維持1.5—3小时(注射給药)和7小时以上(灌胃給药)。多数实驗家兔在子宮兴奋同时有排便現象。該結晶对家兔在位腸管和大鼠后肢血管均有强烈兴奋作用,但对豚鼠支气管肌作用极弱。当給小鼠靜脉注射时,LD₅₀为38.7毫克/公斤。

A CONTRACTIVE INGREDIENT OF UTERI OBTAINED FROM THE CHINESE DRUG KUANG-TI-LUNG (LUMBRICUS KWANGTANGENSIS)

According to Huang Wen-k'uei's method, we separated an oxytocic ingredient from Kwang-Ti-lung.It was a faintly yellow, hygroscopic, needle crystal, and its content in Kwang-Ti-lung was about 0.2 per cent. The crystal at the concentration of 1:250000 produced a progressive rise on the tonus of isolated uterine horns of rats or guinea pigs, and at the concentration of 1:83000, a spastic contraction was apparent. The solution of crystal by intravenous injection to the pregnant or non-pregnant anaesthetized rabbits (1 mg/kg) produced a considerable rise on the tonus of uteri in situ that lasted for 1.5—3 hours, and at a dosage of 8—10 mg/kg, the tonus of uteri raised promptly and the rabbits were dead owing to the blood pressure falling rapidly to zero. From 15 to 45 minutes after intravenous injections (3—6 mg/kg) or oral administrations (10—20 mg/kg) with the solution of crystal to 9 rabbits of chronic uterine fistula, the uterine contractions markedly potentiated; the effect lasted for 1.5—3 hours intravenously and was retained for 7 hours or more orally. The crystal produced also a strong contraction on the rabbit's intestines or the rat's hinder leg vessels, but an extremely weak effect on the guinea pig's bronchial muscles. The LD₅₀ in mice was found to be 38.7mg/kg for the solution, given by intravenous injection.