| 基于网络药理学分析黄芩-黄连药对抗流感的作用机制 |
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| 引用本文： | 李泽明,黄传君,徐淑静,张才擎.基于网络药理学分析黄芩-黄连药对抗流感的作用机制[J].现代中药研究与实践,2021,35(1):16-22. |
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| 作者姓名： | 李泽明 黄传君 徐淑静 张才擎 |
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| 作者单位： | 山东中医药大学中医学院,山东济南250014;山东大学药学院,山东济南250012;山东第一医科大学第一附属医院,山东济南250013 |
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| 基金项目： | 山东省自然科学基金(ZR2014HL003)。 |
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| 摘 要： | 目的 利用网络药理学对黄芩-黄连药对抗流感的作用机制进行分析.方法 利用TCMSP、Swiss和GeneCards数据库筛选黄芩、黄连的有效活性成分,并预测药物和疾病的靶点信息.在Cytoscape软件中构建"药物-成分-疾病-靶点"相互作用网络和蛋白相互作用网络图,并使用R软件对黄芩-黄连药对的作用靶点进行GO与KE...
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| 关 键 词： | 网络药理学 作用机制 黄芩 黄连 流感 |
Analysis of the Mechanism of Herb Pair Containing Scutellariae Radix and Coptidis Rhizoma Against Influenza Based on Network Pharmacology |
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| LI Ze-ming,HUANG Chuan-jun,XU Shu-jing,ZHANG Cai-qing.Analysis of the Mechanism of Herb Pair Containing Scutellariae Radix and Coptidis Rhizoma Against Influenza Based on Network Pharmacology[J].Research and Practice on Chinese Medicines,2021,35(1):16-22. |
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| Authors: | LI Ze-ming HUANG Chuan-jun XU Shu-jing ZHANG Cai-qing |
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| Institution: | (School of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250014,China;School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China;The First Affiliated Hospital of Shandong First Medical University,Jinan 250013,China) |
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| Abstract: | Objective To analyze the mechanism of herb pair containing Scutellariae Radix and Coptidis Rhizoma against influenza based on network pharmacology.Methods Use TCMSP,Swiss and GeneCards databases to screen the active components of Scutellariae Radix and Coptidis Rhizoma,and predict the target information of drugs and diseases.Cytoscape software is used to construct the network of "drug-component-disease-target" interaction and protein interaction network,and the action targets of herb pair containing Scutellariae Radix and Coptidis Rhizoma are analyzed through using R software including GO and KEGG pathway enrichment analysis.Results 49 active components and 123 key targets of herb pair containing Scutellariae Radix and Coptidis Rhizoma are obtained.Flavonoids such as quercetin,baicalin,baicalein and wogonin may be the main active components,which act on the targets of IL6,TNF,CASP3,EGFR and NOS2,participate in several biological processes and play a role of anti-influenza through multiple signal pathways.Conclusion Herb pair containing Scutellariae Radix and Coptidis Rhizoma can resist influenza through the action mechanism of multi-component,multi-target and multi-pathway,which provides a novel idea for the anti-influenza with traditional Chinese medicine. |
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| Keywords: | Network pharmacology action mechanism Scutellariae Radix Coptidis Rhizoma influenza |
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