蓝光联合腺苷蛋氨酸治疗新生儿黄疸疗效研究

目的 探讨蓝光联合腺苷蛋氨酸治疗新生儿黄疸的疗效。方法 2017年5月～2019年5月我院诊治的新生儿黄疸患儿196例,采用随机数字表法将所选患儿分为对照组(n=98)和观察组(n=98)。在对照组患儿,给予蓝光照射治疗,观察组患儿在对照组治疗的基础上给予丁二磺酸腺苷蛋氨酸肠溶片研磨成粉喂服治疗,两组患儿均连续治疗1 w,随访1 w。结果 在随访1 w末,观察组血清丙氨酸氨基转移酶(ALT)水平为(37.1±12.6)U/L,与对照组的【(41.9±11.3)U/L,P>0.05】比,无显著差异,血清天冬氨酸氨基转移酶(AST)水平为(36.2±11.6)U/L,与对照组的【(45.1±13.7)U/L,P>0.05】比,无显著差异,但血清总胆红素(TBIL)水平为(31.2±3.7)μmol/L,显著低于对照组【(62.5±7.1)μmol/L,P<0.05】;血清CRP水平为(8.6±1.3)U/L,显著低于对照组【(11.3±1.9)U/L,P<0.05】,血清磷酸肌酸激酶(CK)水平为(177.7±61.7)U/L,显著低于对照组【(209.6±72.1)U/L,P<0.05】,血清肌钙蛋白激酶同工酶(CK-MB)水平为(3.8±0.4)U/L,显著低于对照组【(5.4±0.9)U/L,P<0.05】,血清乳酸脱氢酶(LDH)水平为(350.5±103.1)U/L,显著低于对照组【(392.6±120.2)U/L,P<0.05】,而血清TRF水平为(1964.8±91.6)U/L,显著高于对照组【(1687.9±88.2)U/L,P<0.05】;观察组不良反应发生率为11.2%,与对照组的14.3%比,无显著性差异(P>0.05)。结论 应用腺苷蛋氨酸辅助蓝光治疗新生儿黄疸可加快黄疸消退,显著改善患儿心肌酶谱改变。

Efficacy of adenosylmethionine and blue light treatment in neonatal jaundice

Objective The aim of this study was to investigate the efficacy of adenosylmethionine and blue light treatment in neonatal jaundice. Methods 196 children with neonatal jaundice were treated in our hospital between May 2017 and May 2019, and they were divided randomly into control (n=98) and observation group (n=98). The neonates in the control group were given blue light illumination (BLI), and those in the observation group were treated with adenosylmethionine succinate enteric-coated tablets and BLI combination for one week. All the children were followed-up for one week. Serum transferrin (TRF) and C-reactive protein (CRP), creatine kinase (CK) , creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH) levels were detected. Results At the end of one week follow-up, in the combination group, serum alanine aminotransferase (ALT) level was (37.1±12.6) U/L, significantly lower than in the control group , serum aspartate aminotransferase (AST) level was(36.2±11.6)U/L, not significantly different as compared to 【(45.1±13.7)U/L, P>0.05】 in the control, while serum bilirubin level was (31.2±3.7) μmol/L, significantly lower than 【(62.5±7.1)μmol/L, P<0.05】 in the control; serum CRP level was (8.6±1.3)U/L, much lower than 【(11.3±1.9)U/L, P<0.05】, serum CK level was (177.7±61.7)U/L, significantly lower than 【(209.6±72.1)U/L, P<0.05】, serum CK-MB level was (3.8±0.4)U/L, significantly lower than 【(5.4±0.9)U/L, P<0.05】, serum LDH level was (350.5±103.1)U/L, significantly lower than 【(392.6±120.2) U/L, P<0.05】, while serum TRF level was (1964.8±91.6)U/L, significantly higher than 【(1687.9±88.2)U/L, P<0.05】 in the control; the incidence of adverse reactions in the observation group was 11.2%, not significantly different as compared to 14.3% (P<0.05) in the control group. Conclusion The administration of adenosine methionine might assist subside jaundice in neonates at the base of BLI treatment, which needs further investigation.