肝硬化并发门静脉血栓患者临床特征及其危险因素分析

目的 总结肝硬化并发门静脉血栓(PVT)患者的临床特征并分析PVT形成的危险因素。方法 回顾性分析2015年2月～2019年2月我院肝胆包虫科治疗的160例肝硬化患者,分析比较PVT组与未发生PVT组患者临床资料的差异,采用多因素分析发生PVT的危险因素。结果 80例PVT患者腹痛、腹水和消化道出血发生率、血小板(PLT)和白细胞(WBC)计数显著高于80例未发生PVT组(P<0.05);经多因素分析,发现PLT计数、糖尿病史和脾切除史为肝硬化并发门静脉血栓形成的独立危险因素(P<0.05)。结论 肝硬化并发PVT患者以HGB、PLT、WBC为主要实验室表现,以腹水、下消化道出血、肝功异常为主要临床症状。PLT、糖尿病史和脾切除史为肝硬化并发门静脉血栓的独立危险因素。

Clinical characteristics and risk factors of portal vein thrombosisin patients with liver cirrhosis

Objective The aim of this study was to analyze the clinical characteristics and risk factors of portal vein thrombosis(PVT)in patients with liver cirrhosis(LC).Methods A retrospective analysis was made on 160 patients with LC admitted to our Department in our hospital from February 2015 through February 2019.The clinical symptoms,laboratory indexes and general data of patients were collected.The multivariate Logistic analysis was applied to evaluate the risk factors of PVT.Results The incidence of abdominal pain,ascites and gastrointestinal hemorrhage,and the platelet(PLT)counts and white blood cell(WBC)counts in 80 patients with PVT were significantly higher than those in 80 patients without PVT;the multivariate Logistic analysis showed that the PLT counts,diabetes and splenectomy were the independent risk factors for PVT in patients with LC(P<0.05).Conclusion The ascites,gastrointestinal hemorrhage and liver dysfunction are the main clinical manifestation in patients with LC and PVT,and the PLT counts,diabetes and splenectomy are the main independent risk factors for portal vein thrombosis.