静脉滴注莫西沙星致过敏性休克

1例75岁女性患者因腰椎手术后预防感染给予盐酸莫西沙星注射液0.4 g(250ml)静脉滴注。用药约10 min后,患者突感全身不适,皮肤湿冷,大汗,心率130次/min,呼吸26次/min,血压57/37 mmHg(1 mmHg=0.133 kPa)。考虑为莫西沙星导致的过敏性休克,立即停用莫西沙星,给予心电监护、鼻导管吸氧、先后静脉注射盐酸肾上腺素注射液0.5 mg、呋塞米注射液10 mg、硝酸甘油注射液2.5 mg,酒石酸美托洛尔片12.5 mg舌下含服。80 min后症状缓解,心率88次/min、呼吸18次/min,血压95/54 mmHg。

Anaphylactic shock caused by an intravenous intusion of moxifloxacin

A 75-year-old female patient received an intravenous infusion of moxifloxacin hydro-chloride injection 0.4g for prevention of infections after lumbar operation.About 10minutes later,the patient developed sudden general discomfort,wet and cold skin,drenching sweats.Meanwhile her heart rate was 130beats/min,breath rate was 26times/min,and blood pressure was 57/37 mmHg.Anaphylactic shock caused by moxifloxacin was considered.Moxifloxacin was stopped immediately,ECG monitoring and oxygen inhalation through nasal catheter were given.Then,intravenous injection of adrenaline hydrochloride injec-tion 0.5 mg,furosemide injection 10mg,nitroglycerin injection 2.5 mg,and sublingual metoprolol tartrate tablet 12.5 mg were given sucessively.After 80minutes,the patient's symptoms relieved,with heart rate 88 beats/min,breath rate 18 times/min,and blood pressure 95/54mmHg.