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Impact of Stereochemistry on Ligand Binding: X-ray Crystallographic Analysis of an Epoxide-Based HIV Protease Inhibitor |
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| Authors: | Fabio Benedetti,Federico Berti,Pietro Campaner,Lidia Fanfoni,Nicola Demitri,Folasade M. Olajuyigbe,Matteo De March,Silvano Geremia | |
| Affiliation: | †Department of Chemical and Pharmaceutical Sciences, Centre of Excellence in Biocrystallography, University of Trieste, Via Giorgeri 1, 34127 Trieste, Italy;‡Department of Biochemistry, Federal University of Technology, P.M.B. 704, Akure 340001, Ondo State, Nigeria | |
| Abstract: | ||
| Keywords: | Epoxide inhibitor HIV protease irreversibleinhibition stereochemistry structure-based drugdesign | |