氟比洛芬酯对全身麻醉术后患者苏醒及镇痛作用的观察

目的:观察氟比洛芬酯对全身麻醉术后患者苏醒及镇痛作用的影响。方法:120例ASAⅠ~Ⅱ级全麻患者,随机分为氟比洛芬酯组(F组)、吗啡组(M组)和对照组(C组),在手术关闭腹膜前,F组给予每例静脉注射氟比洛芬酯50 mg,M组每例静脉注射吗啡4 mg,C组不给药。分别记录苏醒时间、拔管时间、恢复室停留时间,术后8 h内苏醒期并发症发生率,疼痛程度评分,术后2、4、6、8 h内因疼痛需要另外追加镇痛药患者总数。结果:F组清醒时间、拔管时间和恢复室停留时间均短于M组(P<0.01),清醒时间与C组差异无统计学意义(P>0.05),而拔管时间和恢复室停留时间差异均有统计学意义(P<0.01);苏醒期并发症发生率降低;口述评分法(VRS)评分术后2 h各组间差异无统计学意义(P>0.05),术后4、6和8 h,F组和M组疼痛程度明显低于C组(P<0.01),而F组和M组差异无统计学意义(P>0.05)。在术后2、4、6和8 h,各组要求使用镇痛药的人数差异无统计学意义(P>0.05)。结论:手术结束前应用氟比洛芬酯能提供全麻苏醒期间有效的镇痛作用,减少苏醒期并发症的发生率,不影响苏醒过程。

Postoperative palinesthesia and analgesia effect of flurbiprofen axetil on patient receiving general anesthesia

Objective：To observe the postoperative palinesthesia and analgesia effect of flurbiprofen axetil on patients with general anesthesia. Methods：One hundred and twenty patients （ ASA Ⅰ-Ⅱ ） receiving general anesthesia were randomly divided into flurbiprof axetil group（ group F）, morphine group （group M）, control group （group C）. Before the abdominal membrane was closed up, group F were given intravenous injection of flurbiprofen axetil 50 mg, group M intravenous injection of morphine 4 mg and group C not any drugs. The time of palinesthesia, time of extubation, detention time in recovery room, postoperative palinesthesia, incidence rate of complication in eight hours, postoperative analgesia degree score and the number of patients needing to take pain-killing drugs because of pain in 2,4,6 and 8 h after operation were observed. Results：The time of palinesthesia,time of extubation and detention time in recovery room in group F were shorter than that in group M （ P 〈 0.01 ） ; there was no significant difference between group F and group C in the time of palinesthesia（P 〉 0.05 ）, but the defference was significant in time of extubation and detention time in recovery room （P 〈 0. 01 ） ;the incidence of complication was lowered in the time of palinesthesia;VAS score had no statistical difference at 2 h after operation among the 3 groups （P 〉 0.05 ）. The pain degree in group F and group M was signifantly lowered compared with that of group C（P 〈0.01 ）, but the difference was not significant between group F and group M at 4 h,6 h and 8 h after operation（P 〉 0.05 ）. The number of patients needing to take pain-killing drugs in the three groups had no statistical difference at 2 h,4 h, 6 h and 8 h after operation. Conclusions：Administration of flurbiprofen axetil before the end of operation has analgesia effect on patients receiving general anesthesia, and may decrease the incidence of complication at the time of palinesthesia without affecting the course of pali