| 多糖微量元素络合物的安全性试验 |
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| 引用本文： | 潘永全,李逐波.多糖微量元素络合物的安全性试验[J].医学动物防制,1998,14(5):28-30. |
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| 作者姓名： | 潘永全 李逐波 |
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| 作者单位： | 重庆医科大学实验动物中心，重庆医科大学实验动物中心，四川畜牧兽医学院，重庆市饲料质量管理所 重庆 400046，重庆 400046 |
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| 摘 要： | 本研究对多糖微量元素络合物进行了LD_(50)试验、Ames试验、微核试验、蓄积性试验、溶血性试验等安全性试验。其结果为:小白鼠口服的LD_(50)为870.1mgFe/g·BW(即3873.04mg多糖铁),其刺激性弱。多糖Fe、Cu、Zn、Mn混饲小白鼠20d,蓄积系数大于5。Ames试验及微核试验均为阴性,无溶血现象,注射剂热原检查符合《药典》规定。
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| 关 键 词： | 多糖微量元素络合物 安全性 LD_(50)试验 Ames 微核试验 蓄积性试验 |
Experiment on Safety of Complex of Polysaccharide-trace element |
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| Pan Yongquan Wei Ke Li Zhubo.Experiment on Safety of Complex of Polysaccharide-trace element[J].Chinese Journal of Pest Control,1998,14(5):28-30. |
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| Authors: | Pan Yongquan Wei Ke Li Zhubo |
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| Abstract: | We cought out on complex of polysaccharide-trace element LD50 test,Ames test. Micro nuclei test,Storage test and hemolysis test. The results showed that LD50 on mice is 870.1mg Fe/kg · BW (containing 3783. 04mg polysccharide Fe) and stimulus was observed. Storage coefficient was over 5 when mice were raised with polysaccharide Fe,Cu,Zn, Mn complex. The results of Ames and Micronuclei test were negative. No hemolysis took place. Evaluation of heat suurce in injective agents was up to the terms of pharmacopeia. |
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| Keywords: | Complex of polysaccharide-trace element Safety Ld50 Test Ames Test Micro nuclei Test Storage Test |
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