气血注射液防治缺氧性肺动脉高压的研究

本实验观察中药气血注射液、西药钙通道阻断剂异搏定(Vp)及中西药合用对大鼠缺氧性肺动脉高压形成的影响。结果表明,气血注射液及Vp均可明显降低慢性缺氧引起的肺动脉压升高程度,且前者的效果显著优于后者;气血注射液还可显著改善缺氧造成的右心室收缩性能指标(IC)下降,并可使IC接近平原正常值。气血注射液的效果并不因合用Vp而加强。气血注射液、Vp及二者合用对大鼠颈动脉压、心率及左心功能均无明显影响。提示在缺氧过程中,增强心脏代偿能力可能滞延缺氧性肺动脉高压的发展进程。

Prevention of Hypoxic Pulmonary Hypertension with "Qi-Xue" Injection

Effects of "Qi-Xue" injection (Panax ginseng. Astragalus monogholicus, Angelica sinensis), verapamil (Vp, calcium antagonist) and their combination on pulmonary arterial pressure (PAP) and heart function were studied in rats exposed to chronic hypoxia. Male Wistar rats were divided into sea level (n=9), hypoxic (n=8), Chinese herbs (n = 15), Vp (n=20) and herbs Vp (n=18) groups. All the rats, except the SL group, were placed in a hypobaric chamber simulating an altitude of 5000m above sea level for 15 days. During this time, the aforementioned drugs were given i. p. bid every day. It was found that apparent increase of PAP and decrease of IC-R (index of contractility of right ventricle) were induced by hypoxia without signifi- cant change of CAP, HR or left ventricular function. Both "Qi-Xue" injection and Vp minimized the increase in PAP due to hypoxia, with the former being more effective than the latter. "Qi-Xue" injection also attenuated IC-R decrease and kept it in the normal range. No appreciable differences were observed between the effect of "Qi-Xue" and its combination with Vp. It is suggested that "Qi-Xue" injection might prevent the development of severe hypoxic pulmonary hypertension by improving heart function.