| As2O3,MNNG和B（a）P对人胎儿及大鼠气管上皮的致癌... |
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| 引用本文： | 董金堂,罗贤懋.As2O3,MNNG和B（a）P对人胎儿及大鼠气管上皮的致癌...[J].中国医学科学院学报,1990,12(5):380-384. |
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| 作者姓名： | 董金堂 罗贤懋 |
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| 摘 要： |
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| 关 键 词： | As2O3 MNNG 苯并bi 致癌作用 |
Effects of As2O3, MNNG and B(a)P on epithelia of human fetal tracheae and rat tracheae in organ culture |
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| J Dong.Effects of As2O3, MNNG and B(a)P on epithelia of human fetal tracheae and rat tracheae in organ culture[J].Acta Academiae Medicinae Sinicae,1990,12(5):380-384. |
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| Authors: | J Dong |
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| Institution: | Institute of Oncology, Beijing. |
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| Abstract: | The effects of As2O3, MNNG and B(a)P on epithelia of human fetal tracheae and rat tracheae in organ culture were studied. In human fetal trachea, a small dose of arsenic (1 mumol As) induced hyperplasia of the epithelium; 3-9 mumol As induced hyperplasia and cellular atypia in the epithelium, and hyperplasia and squamous metaplasia in the adenoepithelium. Similar effects were not observed in rat tracheae. MNNG and B(a)P induced hyperplasia, squamous metaplasia and dysplasia in human fetal tracheal and rat tracheal epithelia respectively, and MNNG also induced hyperplasia and squamous metaplasia in human fetal tracheal adenoepithelium. The data suggest that 1) arsenic may be carcinogenic to the human respiratory tract but not to the rat; and 2) human tissues in organ culture are very useful for detecting carcinogens and for studying carcinogenesis. |
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