| IL-10启动子-592基因多态性与肠易激综合征的关系 |
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| 引用本文： | 姜英杰,聂玉强,赖晓波. IL-10启动子-592基因多态性与肠易激综合征的关系[J]. 现代医院, 2010, 10(9): 8-10. DOI: 10.3969/j.issn.1671-332X.2010.09.004 |
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| 作者姓名： | 姜英杰 聂玉强 赖晓波 |
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| 作者单位： | 广州市第一人民医院,广东广州,510180 |
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| 基金项目： | 广州市医药卫生科技项目 |
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| 摘 要： | 目的探讨IL-10启动子-592位点基因多态性与肠易激综合征(IBS)的关系。方法采用聚合酶链式反应结合限制性内切酶技术(PCR-RFLP),对312例IBS患者及325例正常对照者的IL-10启动子-592位点进行基因型分析。结果 IL-10启动子-592位点的A等位基因的发生率在IBS组及正常对照组分别为72.8%及68.9%,两组无统计学差异;IL-10启动子-592位点A/A及A/C基因型在IBS组及正常对照组的发生率有统计学差异(p<0.05),A/A基因型在两组的发生率分别为56.1%及46.2%,A/C型分别为33.3%及45.5%。结论 IL-10启动子-592位点A/A基因型可能更易患IBS。
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| 关 键 词： | 肠易激综合征 IL-10 基因多态性 |
IL-10 GENE PROMOTER-592 POLYMORPHISM AND IRRITABLE BOWEL SYNDROME |
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| JIANG Yingjie,NIE Yuqiang,LAI Xiaobo. IL-10 GENE PROMOTER-592 POLYMORPHISM AND IRRITABLE BOWEL SYNDROME[J]. Modern Hospital, 2010, 10(9): 8-10. DOI: 10.3969/j.issn.1671-332X.2010.09.004 |
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| Authors: | JIANG Yingjie NIE Yuqiang LAI Xiaobo |
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| Affiliation: | ( First Municipal People＇s Hospital of Guangzhou,Guangzhou City,Guangdong Province 510180 PRC ) |
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| Abstract: | Objective To investigate the relationship of gene polymorphism of IL-10 gene promoter-592 position with IBS.Methods 312 IBS patients and 325 controls were enrolled to this study.Their IL-10-592 genotyping was detected by PCR-restriction enzyme analysis.Results The incidences of IL-10-592 A allele frequency in IBS and control group were 72.8% and 68.9%,respectively（p〈0.05）.Differences were significant of A/A and A/C genotypes between IBS and control （p〈0.05）.Conclusion The presence of-592 A/A genotype may be related to development of IBS. |
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| Keywords: | IL-10 |
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