Changes in hypoxia resistance in rats during daytime |
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| Authors: | M. L. Khachatur'yan L. A. Panchenko E. N. Zanina S. M. Perevertkin N. A. Agadzhanyan |
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| Affiliation: | (1) Department of Experimental and Laboratory Models, Russian State Medical University, Moscow;(2) Department of Zoology of Vertebrates and General Ecology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow;(3) Department of Higher Mathematics, Medico-Biological Faculty, Russian State Medical University, Moscow;(4) Department of Radioelectronic Devices and Systems, Moscow State Technical University, Moscow;(5) Department of Normal Physiology, Russian University of Peoples' Friendship, Moscow |
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| Abstract: | The resistance to acute hypoxia in male Wistar rats was evaluated by the period of survival after exposure to high-altitude hypoxia (11.5 km above see level). The study was performed during daytime (13.00–21.00) in autumn. The fatal rat population was characterized by the log-normal distribution of survival periods. The rats with low and moderate resistance to hypoxia exhibited similar diurnal variations in it with gradual decrease by the end of daytime more pronounced in low-resistant rats. The rats with high resistance showed relatively constant resistance to hypoxia which decreased only at 21:00. All groups revealed a relatively stable resistance to hypoxia from 16:00 to 18:00. These variations in the resistance to hypoxia should be taken into consideration when planning experimental research. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 3, pp. 256–260, March 1999 |
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| Keywords: | resistance to hypoxia diurnal rhythm |
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