氨氯地平配伍厄贝沙坦治疗90例原发性高血压的临床疗效分析

目的:探讨氨氯地平配伍厄贝沙坦治疗原发性高血压的临床疗效。方法:选择2012年1-12月诊断为原发性高血压的门诊及住院患者90例,按随机数字表法分为观察组和对照组各45例,对照组应用氨氯地平片;观察组在此治疗基础上配伍应用厄贝沙坦片。以治疗过程中血压值及常规检查项目作为治疗效果检测指标。结果:2个疗程结束后,两组患者收缩压与舒张压相比治疗前均有下降,观察组血压下降幅度与对照组比较差异有统计学意义(P0.05)。观察组总有效率93.3%,对照组总有效率73.3%,两组总有效率比较差异有统计学意义(P0.05)。观察组有3例出现头晕、头痛、面部潮红不良反应,对照组出现2例类似不良反应,两组比较差异无统计学意义(字2=0.21,P0.05)。肝肾功能、生化指标及心电图改变两组均未有异常。结论:氨氯地平配伍厄贝沙坦治疗原发性高血压患者,降压效果较好,且使用安全,稳定持久,故在考虑降压药物时可以将此作为首选治疗方案。

Clinical Effects of Amlodipine Combined Irbesartan in Treatment of Hypertension

Objective： To explore the clinical efficacy of amlodipine eombined irbesartan in treatment of hypertension. Method： 90 patients who were diagnosed hypertension outpatients or inpatient were chosen in our hospital from Jan 2012 to Dec 2012, and randomly divided into observation group and control group, each of 45 cases. The control group were given amlodipine and the observation group were given irbesartan besides amlodipine.Blood pressure values and routine examination and treatment effect were regared as detection index after two courses of treatment.Result： After two courses, systolic and diastolic blood pressure of two groups were decreased. Compared to the control group, the observation group had significant decrease in blood pressure difference （ P〈0.05 ） .The total effective rate of observation group was 93.3%, and the control group was 73.3%, total effective rate difference was significant （ P〈0.05 ） .Three cases had dizziness, headache, facial flushing adverse reactions in the observation group, 2 cases had adverse reactions in the control group, the difference was not statistically significant （ X 2=0-21, P〉0.05 ） .Conclusion： Antihypertensive effect of amlodipine combined irbesartan is good in treatment of hypertension, and it is safe, stable and lasting, so it is considered as the first-choice drug of ant/hypertensive treatment.