茵栀黄注射液治疗婴儿肝炎综合征的疗效及安全性分析

目的：探讨茵栀黄注射液治疗婴儿肝炎综合征的疗效及安全性。方法：将100例肝炎综合征婴儿按照抽签方法随机均分为对照组与观察组，每组各50例。对照组给予常规保肝治疗，观察组在此基础上给予茵栀黄注射液进行治疗。比较两组临床疗效、治疗前后肝脾消肿情况、治疗前后血清总胆红素（TBil）、总丙氨酸转氨酶（sALT）、天冬氨酸转氨酶（AST）以及治疗过程中不良反应发生情况。结果：对照组临床治疗总有效率为66.00%，明显小于观察组的92.00%（P〈0.05）；对照组治疗前后肝、脾脏大小比较差异无统计学意义（P〈0.05）；观察组治疗前后比较差异有统计学意义（P〈0.05），且观察组治疗后与对照组比较差异也具有统计学意义（P〈0.05）；两组治疗前后TBil、sALT及AST比较差异均具有统计学意义（P〈0.05），且观察组治疗后与对照组比较差异均具有统计学意义（P〈0.05）；两组治疗过程中均未出现任何不良反应。结论：茵栀黄注射液治疗婴儿肝炎综合征的疗效显著，且安全性高，值得在临床上加以推广并应用。

Safety Analysis of Yinzhihuang Injection in the Treatment of Infantile Hepatitis Syndrome

Objective：To investigate safety analysis of Yinzhihuang injection in the treatment of infantile hepatitis syndrome. Method：100 cases of hepatitis syndrome infants randomly according to balloting were divided into control group and observation group,50 cases in each group. The control group received conventional liver treatment,on the basis of the control group,the observation group were given Yinzhihuang injection treatment. Clinical efficacy,liver and spleen swelling,treatment serum total bilirubin（TBil）,total alanine aminotransferase（sALT）,aspartate aminotransferase（AST） before and after treatment of the two groups were compared and observed the treatment of adverse events during. Result：In the control group,the clinical total effective rate was 66.00%,significantly less than the observation group（92.00%）（P〈0.05）;the control group before and after treatment of liver, spleen size were no significant difference（P＆gt;0.05）,but before and after treatment was compared,the differences were statistically significant（P〈0.05）, and the observation group after treatment compared with the control group after treatment,the difference was statistically significant（P〈0.05）;before and after treatment,TBil,sALT and AST compared,the differences were statistically significant（P〈0.05）and the observation group after treatment compared with the control group after treatment,the differences were statistically significant（P〈0.05）;during the treatment groups had no any adverse reaction. Conclusion：Yinzhihuang injection treatment of infantile hepatitis syndrome significant,and safe,it is worth to be promoted in clinical and applied.