大肠癌中VEGF、Ki-67和MVD的检测及其临床意义 |
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引用本文: | 焦亚莉,杨丽娟,朱蕾,陈蕾,霍亚平. 大肠癌中VEGF、Ki-67和MVD的检测及其临床意义[J]. 现代保健, 2014, 0(4): 34-36 |
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作者姓名: | 焦亚莉 杨丽娟 朱蕾 陈蕾 霍亚平 |
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作者单位: | [1]河南省安阳市第六人民医院,河南安阳455000 [2]河南省安阳市第二人民医院,河南安阳455000 |
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摘 要: | 目的:探讨大肠癌组织VEGF、Ki-67的表达和微血管密度(MVD)及其临床意义。方法:应用免疫组化SP法检测60例大肠癌组织中VEGF、Ki-67的表达和MVD,并分析其临床特征及相关性。结果:大肠癌VEGF、Ki-67的阳性表达率分别为76.7%、73.2%,明显高于癌旁肠组织的35.0%、20.1%。两者比较差异均有统计学意义(P〈0.05);VEGF阳性率在有/无淋巴结转移的大肠癌中差异显著(P〈0.05);VEGF阳性表达组MVD值显著高于阴性组(P〈0.05)。结论:VEGF与大肠癌的发生、发展和转移密切相关,提示阻断VEGF通路将对大肠癌的治疗提供新的靶点。Ki-67是肿瘤良恶性鉴别、提示预后的重要指标。
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关 键 词: | 大肠肿瘤 血管内皮生长因子 微血管密度 Ki-67 Ki-67 |
Significance of VEGF,Ki-67 and Intratumour MVD in Colorectal Carcinomas |
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Affiliation: | JIAO Ya-li, YANG Li-juan, ZHU Lei, et al( The Sixth People's Hospital of Anyang City, Anyang 455000, China) |
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Abstract: | Objective:To investigate effect of the expression of vascular endothelial growth factor(VEGF),Ki-67 and on intratumour microvessel density(MVD)in colorectal carcinoma tissues. Method:The immunohistochemical(SP method)was used to detect the expression of VEGF, Ki-67 and MVD in 60 cases of colorectal carcinomas,analyzed the clinical pathological characteristics and correlation. Result:The positive expression rates of VEGF and Ki-67 of colorectal carcinoma were 76.7%and 73.2%,which were higher than that in adjacent non-neoplastic tissue(35.0%and 20.1%)(P〈0.05). The expression of VEGF in colorectal carcinoma was correlated with lymph node metastasis(P〈0.05). The expression of VEGF was correlated with MVD(P〈0.05). Conclusion:VEGF might have important significance in the carcinogenesis,progression and metastasis of colorectal carcinoma,and VEGF might be as a potentially useful target for therapeutic intervention in colorectal carcinoma patients. Ki-67 plays an important value in differential diagnosis and prognosis of the tumour. |
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Keywords: | Colorectal neoplasms VEGF MVD |
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