不同剂量辛伐他汀治疗高脂血症的临床疗效观察

目的:观察分析不同剂量的辛伐他汀治疗高脂血症的临床疗效,为临床合理用药提供参考。方法:选取2009年1月-2012年12月本院收治的高脂血症患者382例,双盲法随机分为小剂量组(辛伐他汀20 mg/d)和大剂量组(辛伐他汀40 mg/d),每组各191例。连用8周,观察两组治疗前后的胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)水平的变化,比较两组疗效,监测不良反应。结果:大剂量组的TC、LDL-C、HDL-C、TG水平较小剂量组均改善明显(P0.05);大剂量组总有效率为89.53%,优于小剂量组的78.01%(P0.05);两组均表现出良好耐受性,未发现严重不良反应。结论:大剂量辛伐他汀治疗高脂血症疗效确切,安全性较高。

Clinical Curative Effect of Different Doses of Simvastatin Treatment on Hyperlipidemia

Objective：To observe and analyze the clinical curative effect of different doses of simvastatin treatment on hyperlipidemia,to provide reference for clinical rational drug use. Method：382 patients with hyperlipidemia in our hospital from January 2009 to December 2012 were selected and divided into low-dose group（20 mg/d）and high-dose group（40 mg/d）by double-blind randomized,each group had 191 cases. Ed eight weeks,observed changes of cholesterol（TC）,low-density lipoprotein cholesterol（LDL-C）,high density lipoprotein cholesterol（HDL-C）,triglyceride（TG）level of two groups before and after treatment,compared the clinical curative effect of two groups,monitored the adverse reactions.Result：TC,LDL-C,HDL-C, TG levels of High-dose group were improved significantly than small dose group（P〈0.05）;High-dose group total effective rate was 89.53%and better than that of small dose group（78.01%）（P〈0.05）;Both groups showed good tolerability,found no serious adverse reaction.Conclusion：High-dose simvastatin treatment of hyperlipidemia has curative effect,high safety.