功能性消化不良伴焦虑Hp感染者根除Hp治疗疗效观察

目的:对幽门螺杆菌(helicobacter pylori,Hp)感染功能性消化不良(functional dyspepsia,FD)伴焦虑者根除Hp治疗,研究根除Hp治疗的必要性。方法:选择85例FD伴焦虑症状Hp感染患者,分为治疗组42例和对照组43例,治疗组在常规治疗的的基础上进行根除Hp治疗,对照组采用常规治疗。比较两组患者治疗结束后6个月、12个月的ZUNG焦虑自评量表评分和疗效。结果:治疗6个月后,治疗组总有效率为64%,对照组为40%,两组比较差异有统计学意义(P0.05);治疗12个月后,治疗组总有效率为69%,对照组为43%,两组比较差异有统计学意义(P0.05)。治疗后6个月和12个月,ZUNG焦虑自评量表评分两组比较差异均有统计学意义(P0.01)。结论:FD伴焦虑症状的Hp感染者在常规治疗的基础上根除Hp治疗,对改善FD伴焦虑症状疗效优于常规治疗,Hp感染存在诱发或加重焦虑症状的倾向,应进行根除Hp治疗。

The Curative Effect Observation of Hp Eradication Therapy for the Anxiety FD Patients with HP Infection

Objective：To study the necessities of Hp eradicate therapy in anxiety FD patients with Hp infection.Method：85 FD with anxiety Hp infected patients were divided into 2 groups：the treatment group and the control group. The treatment group with 42 cases were accept the Hp eradicate therapy on the basis of conventional treatment,while the control group with 43 cases were just accept the conventional treatment. The indicators between the two groups were compared after treatment 6 months and 12 months,such as the effective rate,the self-rating anxiety scale of ZUNG point.Result：The total effective rate of the treatment group for 6 months was 64%,for 12 months was 69%,while the total effective rate of the control group for 6 months was 37%,for 12 months was 43%,and the difference between the two groups were all statistically significant（P〈0.05）.The ZUNG self rating anxiety scale score of the treatment group for 6 months and 12 months were significant lower than the control group（P〈0.01）.Conclusion：FD with anxiety patients who accept the Hp eradicated therapy on the basis of conventional treatment have a better curative effect than only accept conventional treatment. The infection of the Hp may induce or exacerbate the anxiety tendency of the FD patients. Patients infected with FD and anxiety Hp should accept the Hp eradication therapy.