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| 白藜芦醇对软脂酸钠诱导的肝细胞脂肪变性的影响 | |
| 引用本文： | 王光丽,傅玉才,冯雅卿,周小辉.白藜芦醇对软脂酸钠诱导的肝细胞脂肪变性的影响[J].汕头大学医学院学报,2009,22(1):9-11. |
| 作者姓名： | 王光丽 傅玉才 冯雅卿 周小辉 |
| 作者单位： | 1. 汕头大学医学院第一附属医院感染科;汕头大学医学院细胞衰老实验室,广东汕头515041 2. 汕头大学医学院细胞衰老实验室,广东汕头,515041 3. 汕头大学医学院第一附属医院感染科 |
| 摘 要： | 目的：研究白藜芦醇对软脂酸钠诱导的细胞内甘油三酯沉积的影响。方法：用软脂酸钠诱导法使HepG2细胞内甘油三酯沉积，建立细胞脂肪变性模型，将实验分为对照、白藜芦醇、高脂及高脂＋白藜芦醇组，用油红O染色法定量检测各组细胞内甘油三酯的浓度。结果：0．2mmoL软脂酸钠可引起明显的细胞内甘油三酯沉积（P〈0．05），而40μmoL白藜芦醇则可抑制软脂酸钠的这一效应，使细胞内的脂质浓度几乎降至基线水平。结论：白藜芦醇可改善软脂酸钠诱导的肝细胞脂肪变性。 |
| 关 键 词： | HepG2细胞 脂肪变性 软脂酸钠 白藜芦醇 |
Effect of Resveratrol on Steatosis in HepG2 Cells Induced by Sodium Palmitate |
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| WANG Guang-li,FU Yu-cai,FENG Ya-qing,ZHOU Xiao-hui.Effect of Resveratrol on Steatosis in HepG2 Cells Induced by Sodium Palmitate[J].Journal of Shantou University Medical College,2009,22(1):9-11. | |
| Authors: | WANG Guang-li FU Yu-cai FENG Ya-qing ZHOU Xiao-hui |
| Institution: | WANG Guang-li, FU Yu-cai, FENG Ya-qing, ZHOU Xiao-hui (1.Department of Infectious Diseases, The First Affiliated Hospital, Shantou University Medical College, Shantou 51504I, China, 2. Laboratory of Cell Senescence, Shantou University Medical College, Shantou 515041, China) |
| Abstract: | Objective： To investigate the effect of resveratrol on triglyceride accumulation in HepG2 cells induced by sodium palmitate. Methods： The cell model of steatosis was established using sodium palmitate in HepG2 cells. The experiments were divided into control, resveratrol, high fat, high fat ＋ resveratrol groups. The amount of triglyceride in HepG2 cells was quantitatively analyzed by oil red O staining method. Results： The sodium palmitate（0.2 mmoL）resulted in significantly steatosis in HepG2 cells, the resveratrol（40 μmoL）inhibited the effect of sodium palmitate, and reduced the fat amount nearly to the basal level. Conclusion： Resveratrol is able to ameliorate the excessive triglyceride accumulation in HepG2 cells induced by sodium palmitate. |
| Keywords: | HepG2 cell steatosis sodium palmitate resveratrol |
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