50例高血压患者内皮素和一氧化氮与血压节律相关性的研究

目的探讨高血压患者血浆内皮素(ET)和血清一氧化氮(NO)与血压节律的相关性.方法 50例高血压患者和25例血压正常人进行动态血压监测和ET、NO测定.结果高血压组ET增加,NO下降.将选出的50例高血压患者按动态血压监测结果分为勺型和非勺型组,在非勺型组,ET明显增高(54.2±18.9)vS(37.7±10.1)ng/L,NO明显降低(32.9±12.8)VS(48.7±11.2)mg/L;且夜间血压下降与ET负相关(r=0.51,P＜0.05),NO正相关(r=0.53,P＜0.05).结论高血压病患者内皮素和一氧化氮水平可能参与昼夜血压节律的调节.

Endothelin, nitric oxide and blood pressure rhythm in 50 patients with essential hypertension

Objective:To evaluate relationship between endothelin, nitric oxide and ciradian rhythm of blood pressure in essential hypertension. Methods :50 Patients with essential hypertensitn and 25 patients with normotension were monitored 24 hour blood pressure and examined endothelin , mitric oxide. Results:In hypertension group, ET increased and NO decreased: According to results of the monitoring, 50 patients hypertension were divided dipper hy pertension and non - dipper hypertension. In non - dippers, endothelin was significantly higher (54.2 ± 18.9) VS (37.7 ± 10.1) ng/L,nitric oxide was lower (32.9 ± 12.8) VS (48.7 ± 11.2) mg/L. There were significant negative correlation between nocturnal blood pressure fall and endothelin (r = -0.51, P ＜ 0.05 ), positive correcation between noctural blood pressure fall and nitric oxide) ( r = 0.53, P ＜ 0.05 ). Conclusions: Endothelin and nitric oxide might have effects in circadian rhythm of blood pressure in essential hypertension.