| 改善美洛昔康体外经皮渗透的研究 |
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| 引用本文： | 黄齐慧,成明建. 改善美洛昔康体外经皮渗透的研究[J]. 黑龙江医药, 2007, 20(6): 584-585 |
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| 作者姓名： | 黄齐慧 成明建 |
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| 作者单位： | 广东云浮市人民医院,527300;广东云浮市人民医院,527300 |
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| 摘 要： | 目的:研究几种常用促渗剂对美洛昔康体外经皮渗透的影响,改善美洛昔康体外经皮.方法:用紫外分光光度法检测浓度,采用改进Franz扩散池,比较几种常用促渗剂对美洛昔康渗透速率的影响.结果:氮酮(Azone)单独使用不能明显提高美洛昔康的渗透速率(P>0.05),而丙二醇.薄荷醇、丙二醇 Azone(1:1),丙二醇 薄荷醇(1:1)能显著提高美洛昔康的渗透速率(P<0.01).结论:丙二醇、薄荷醇、丙二醇 Azone(1:1)、丙二醇 薄荷肆(1:1)可作为促渗剂用于美洛昔康经皮吸收制剂.
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| 关 键 词： | 美洛昔康 1-2丙二醇 薄荷醇 氮酮 |
| 文章编号： | 1006-2882（2007）06-584-02 |
| 修稿时间： | 2007-05-10 |
Study on the Improvement of the Permeability of Meloxicam through Skin in Vitro |
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| HuangQihui,et al. Study on the Improvement of the Permeability of Meloxicam through Skin in Vitro[J]. Heilongjiang Medicine, 2007, 20(6): 584-585 |
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| Authors: | HuangQihui et al |
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| Abstract: | Objective:To study the effects of several penetration enhancers on the permeation of Meloxicam through skin in vitro and improve it.Methods:UV-Spectrophotometry and improved Franz diffusion cell were used to compare the influence of several penetration enhancers on the permeability of Meloxicam.Results:Exclusive use of Azone had little en- hancement effect on the permeability of Melxicam(P>0.05).Propylene glycol,menthol,Azone/propylene glycol(1:1.men- thol/propylene glycol(1:1)showed marked enhancement effects on the permeability of Meloxicam(P<0.01). Conclusion:propylene glycol,menthol,Azone/propylene glycol(1:1),menthol/propylene glycol(1:1)were found to be the proper penetration enhancers in the transdermal preparations of Meloxicam. |
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| Keywords: | Meloxicam propylene glycol menthol Azone |
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