| The Clinical Significance of Anti-LSP Antibodies in the Sera of Patients with Viral Hepatitis:An Evaluation with ELISA and SPA-RIA |
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| 作者姓名： | 李梦东 何长清 郑智勇 程懋坪 |
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| 作者单位： | Department of Infectious Disease Second Teaching Hospital，Third Military Medidal College，Chongqing，Department of Infectious Disease，Second Teaching Hospital，Third Military Medidal College，Chongqing，Department of Infectious Disease，Second Teaching Hospital，Third Military Medidal College，Chongqing，Department of Infectious Disease，Second Teaching Hospital，Third Military Medidal College，Chongqing |
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| 摘 要： | Antibodies against LSP in the sera of 163 patients with various typesof viral hepatitis were determined with SPA-RIA.The sera of anothergroup of 118 patients(109 of them were from the first group)withviral hepatitis were studied with ELISA for the same antibodies,whichwere further divided into three categories,that is,IgG,IgM,and IgAclasses.The results of 109 patients examined with both of the two me-thods indicated that anti-LSP antibodies measured by SPA-RIA mightmainly represent anti-LSP IgG class.It was found that circulating anti-LSP antibodies could easily be detected in most patients with either acuteor chronic hepatitis.After analyzing the results,the authors suggest thatthe humoral immune response against LSP might not be the sole initiatingfactor in the pathogenesis of viral hepatitis,they are more likely theresult of the antigen variation of the injured liver cells.
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The Clinical Significance of Anti-LSP Antibodies in the Sera of Patients with Viral Hepatitis:An Evaluation with ELISA and SPA-RIA |
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| Li Mengdong He Changqing Zheng Zhiyong Cheng Maoping.The Clinical Significance of Anti-LSP Antibodies in the Sera of Patients with Viral Hepatitis:An Evaluation with ELISA and SPA-RIA[J].Journal of Medical Colleges of PLA(China),1986(2). |
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| Authors: | Li Mengdong He Changqing Zheng Zhiyong Cheng Maoping |
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| Institution: | Li Mengdong He Changqing Zheng Zhiyong Cheng Maoping Department of Infectious Disease,Second Teaching Hospital,Third Military Medidal College,Chongqing |
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| Abstract: | Antibodies against LSP in the sera of 163 patients with various types of viral hepatitis were determined with SPA-RIA.The sera of another group of 118 patients(109 of them were from the first group)with viral hepatitis were studied with ELISA for the same antibodies,which were further divided into three categories,that is,IgG,IgM,and IgA classes.The results of 109 patients examined with both of the two me- thods indicated that anti-LSP antibodies measured by SPA-RIA might mainly represent anti-LSP IgG class.It was found that circulating anti- LSP antibodies could easily be detected in most patients with either acute or chronic hepatitis.After analyzing the results,the authors suggest that the humoral immune response against LSP might not be the sole initiating factor in the pathogenesis of viral hepatitis,they are more likely the result of the antigen variation of the injured liver cells. |
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| Keywords: | liver specific membrane lipoprotein(LSP) staphylococcal protein A radioimmunoprecipitation assay(SPA-RIA) enzyme linked immnosorbent assay(ELISA)chronic active hepatitis(CAH) chronic persistent hepatitis(CPH) |
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