| 补肾、健脾及脾肾双补对地塞米松诱发之骨质疏松大鼠PTH、CT、T、E2及BGP值影响的实验研究 |
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| 引用本文： | 陈东煜,沈培芝,徐宇,石印玉. 补肾、健脾及脾肾双补对地塞米松诱发之骨质疏松大鼠PTH、CT、T、E2及BGP值影响的实验研究[J]. 实用骨科杂志, 2002, 8(2): 105-107 |
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| 作者姓名： | 陈东煜 沈培芝 徐宇 石印玉 |
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| 作者单位： | 1. 上海中冶医院骨科,上海,200941
2. 上海中医药大学骨伤科研究所,上海,200021 |
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| 摘 要： | 目的：探讨补肾，健脾及补肾合健脾三种中药防治由地塞米松诱发之大鼠骨质疏松的效果及作用机制，为临床用药及进一步有效筛选中药提供依据。方法：采用12月龄的老年SD大鼠，随机分为5组，给予地塞米松造模，于中药治疗后6w和13w测定骨密度，血清降钙素，骨钙素，性激 素及甲状旁腺素，结果：三种方药均可有效地改善骨质疏松症状，补肾中药以增高性激素浓度尤其是血清睾酮为主，健脾则通过降低甲状旁腺素（PTH）来抑制骨的吸收，而补肾和健脾则可协同提高血清降钙素（CT）的浓度。结论：补肾，健脾及补肾合健脾在不同环节通过不同的作用机制防治骨质疏松。
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| 关 键 词： | 骨质疏松 中药治疗 骨钙代谢激素 动物实验 地塞米松 作用机制 |
| 文章编号： | 1008-5572(2002)02-0105-03 |
| 修稿时间： | 2001-08-10 |
The Experiment Study of Effect on PTH CT T E2 and BGP by Chinese HerbBushen Jianpi and Pishenshuangbu to Osteoporosis Rats Established by Dexamethasone |
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| CHEN Dongyu,SHEN Peizhi,XU Yu,et al. The Experiment Study of Effect on PTH CT T E2 and BGP by Chinese HerbBushen Jianpi and Pishenshuangbu to Osteoporosis Rats Established by Dexamethasone[J]. Journal of Practical Orthopedics, 2002, 8(2): 105-107 |
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| Authors: | CHEN Dongyu SHEN Peizhi XU Yu et al |
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| Abstract: | Objective:To study the efficacy and mechanism of Chinese Herb BGuShen JianPi and PiShuangBu to osteoporosis rats established by Dexamethasone(DM).Methods:Fifty male Sprague-Dawley rats at the age of 12 month being divided into five groups and being administered appropriately by DM and Chinese Herbs.Results:All three therapy could improve the symptom of osteoporosis effectively.BuShen herb could increase sex hormone chroma in serum even T.JianPi herb could inhibit bone absorbing by decreasing PTH in serum and PiShenShuangBu could increase CT chroma in serum cooperatively.Conclusion:Both BuShen JinaPi and Pi ShneShuangBu could prevent and treat osteoporosis from different link. |
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| Keywords: | Osteoporosis Treatment by Chinese Herb Osteo-Calcium Metabolism Hormong |
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