草苁蓉环烯醚萜苷对移植鳞癌VX2荷瘤兔的抑瘤作用

目的 :探讨草苁蓉环烯醚萜苷(IGBR)对兔VX2移植瘤的生长抑制作用和血清抗氧化活性的影响。 方法 :建立兔皮下VX2移植瘤模型,将实验动物分为模型组、IGBR高、低剂量组和氟尿嘧啶(5-Fu)组,观察各组荷瘤兔的生存情况。另选一批实验动物,连续ig给药21 d后处死动物,剥离肿瘤组织,称瘤重和计算抑瘤率,并比色法检测血清谷胱甘肽- S -转移酶(GST)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-PX)活性及丙二醛(MDA)含量。 结果 :与模型组相比,IGBR能显著延长VX2荷瘤兔生存时间,提高其生命延长度;显著减小移植瘤瘤重,提高抑瘤率。同时,IGBR可明显升高血清SOD,CAT和GSH-PX活性,降低MDA水平。 结论 :IGBR可提高VX2荷瘤兔生存时间,对VX2移植瘤具有明显的抑制作用,其作用可能与其增高机体抗氧化能力有关。

Anti-tumor Effect of Iridoid Glucosides from Boschniakia rossica in VX2-bearing Rabbits

Objective: To investigate the anti-tumor and antioxidative effect of iridoid glucosides from Boschniakia rossica (IGBR) in VX2-bearing rabbits. Method: The VX2 transplanted rabbit model was established and the rabbits were randomly divided into 4 groups: model, high and low dose IGBR, and 5-Fu. Animals were treated with IGBR and the survival times of rabbits were recorded. In additional groups of rabbits treated with IGBR for 21 days, then the tumor weights were estimated and the growth inhibition ratios were calculated, and the serum activities of glutathione S -transferase (GST), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-PX), as well as the content of malondialdehyde (MDA) were detected by colorimetric method. Result: The administration with IGBR prolonged the survival time, inhibited the growth of transplanted tumor, increased the serum activities of SOD, CAT and GSH-PX, and reduced the serum MDA level in VX2-bearing rabbits. Conclusion: IGBR could prolong the survival time of VX2-bearing rabbits, exhibit an inhibitory effect on the growth of transplanted VX2 tumor, probably via the improved anti-oxidative capability.