A possible association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and the personality trait of harm avoidance in Japanese healthy subjects |
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Authors: | Hashimoto Ryota Noguchi Hiroko Hori Hiroaki Ohi Kazutaka Yasuda Yuka Takeda Masatoshi Kunugi Hiroshi |
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Institution: | The Osaka-Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. hashimor@psy.med.osaka-u.ac.jp |
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Abstract: | Catechol-O-methyltransferase (COMT) is an enzyme that degrades various biogenic amines, which have been hypothesized to be associated with personality traits. We investigated a possible relationship between the COMT Val158Met polymorphism and personality traits assessed by the Temperament and Character Inventory (TCI) in 139 healthy subjects in a Japanese population. The number of Met alleles of the COMT Val/Met genotype tended to relate to harm avoidance (HA) scores parametrically, while no significant difference was observed between genotype groups in either novelty seeking, reward dependence, persistence, self-directedness, cooperativeness or self-transcendence. These results suggest that the Val/Met polymorphism of the COMT gene may play a role in HA in Japanese population. |
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Keywords: | Catechol-O-methyltransferase (COMT) Temperament and Character Inventory (TCI) Harm avoidance Polymorphism |
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