替米沙坦和氯沙坦治疗高血压的Meta分析

目的:评价替米沙坦治疗高血压的有效性和安全性。方法:应用Meta分析对5篇研究替米沙坦与氯沙坦治疗高血压有效性、安全性的文献进行同质性检验及合并效应量估计。结果:5篇随机对照试验,共771例患者符合纳入标准,其中高质量研究2篇。Meta分析结果显示,替米沙坦与氯沙坦比较,降压有效性有统计学意义(比值比1.55,95%可信区间(1.12,2.16),P<0.05),安全性差异无统计学意义(比值比1.03,95%可信区间(0.70,1.53),P>0.05)。结论:替米沙坦治疗高血压的疗效总体上优于氯沙坦,而安全性无差异。

Meta-analysis of Telmisartan vs Losartan in the Treatment of Hypertension

OBJECTIVE： To evaluate the efficacy and safety of telmisartan in the treatment of hypertension. METHODS： The efficacy and safety of telmisartan versus losartan in treating hypertension reported in 5 studies were comprehensively evaluated with the meta- analysis in homogeneity test and combined test. RESULTS： Of the five randomized controlled trials （RCT） in which 771 patients who met the inclusion criteria were included, two studies were of high methodological quality according to Jadad scale. Meta analysis indicated that there was statistical significance between telmisartan and losartan in effectiveness （OR ： 1.55, 95% confidence interval （1.12, 2.16）, P 〈 0.05）, but no statistical significance was noted in safety （OR= 1.03, 95% confidence interval （0.70, 1.53）, P〉 0.05） . CONCLUSION： The effectiveness of telmisartan in the treatment of hypertension is significantly higher than that of losartan; however, there is no signficant differce in safety between the two drugs.