| 建立大鼠胸部创伤模型的简单方法 |
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| 引用本文： | 陈渊,张鹏.建立大鼠胸部创伤模型的简单方法[J].天津医科大学学报,2011,17(1):113-116. |
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| 作者姓名： | 陈渊 张鹏 |
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| 作者单位： | 天津医科大学总医院心胸外科,天津,300052 |
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| 摘 要： | 目的：建立一种简单可靠的胸部创伤模型,反映胸部创伤后的病理生理变化。方法：健康Wistar大鼠36只,随机分为A、B、C、D 4组,分别按照0.4 J/100 g体重、0.6 J/100 g体重、0.8 J/100 g体重和1.0 J/100 g体重采用自行研制的自由落体动物撞击装置对大鼠胸部进行撞击。24 h后对存活大鼠尸检并判断伤情,取损伤肺组织做病理检查。结果：创伤后大鼠呼吸明显加快,A~D组大鼠24 h死亡率分别为0、0、66.7%和100%。损伤评分与创伤能量相关,病理结果显示肺损伤随着创伤能量的增加而加重。结论：自行研制的自由落体式小型生物创伤机适合大鼠胸部创伤模型的建立,适合的创伤能量为0.6 J/100 g体重。
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| 关 键 词： | 胸部创伤 大鼠 模型 |
Simple method of establishing rats chest trauma model |
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| CHEN Yuan,ZHANG Peng.Simple method of establishing rats chest trauma model[J].Journal of Tianjin Medical University,2011,17(1):113-116. |
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| Authors: | CHEN Yuan ZHANG Peng |
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| Institution: | CHEN Yuan,ZHANG Peng(Department of Cardiothoracic,General Hospital,Tianjin Medical University,Tianjin 300052,China) |
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| Abstract: | Objective: To establish an appropriate chest trauma model which could reflect the path physiology change after chest trauma.Methods: 36 healthy Wistar rats were divided into four groups of A,B,C,D.The chest of rats were hit by self-made freely falling body animal wound installation with 0.4 J/100 g,0.6 J/100 g,0.8 J/100 g and 1.0 J/100 g body weight respectively.24 hours later,the traumatic condition was judged by necropsy,and wound lung tissues were observed by pathology.Results: The mortality of group A ~... |
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| Keywords: | Chest trauma Rat Model |
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