| 血管性痴呆小鼠海马突触后致密物95表达的研究 |
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| 引用本文： | 王冰,王佩,康军,田悦平. 血管性痴呆小鼠海马突触后致密物95表达的研究[J]. 脑与神经疾病杂志, 2007, 15(4): 258-259,265 |
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| 作者姓名： | 王冰 王佩 康军 田悦平 |
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| 作者单位： | 050051,河北医科大学第三医院神经内科;河北医科大学第二医院神经内科 |
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| 摘 要： | 目的:探讨血管性痴呆(vascular dementia,VD)小鼠海马突触后致密物95(postsynaptic density95,PSD-95)表达的变化。方法:双侧颈总动脉线结,反复缺血-再灌注法制备小鼠VD模型,跳台试验观测其行为学改变,免疫组织化学方法观察海马齿状回PSD-95的表达。结果:模型组小鼠学习、记忆成绩下降(P<0.05),其海马齿状回(dentategyrus,DG)PSD-95免疫阳性产物较对照组明显减少(P<0.05)。结论:VD模型小鼠学习记忆能力下降可能与海马PSD-95的表达减少有关。
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| 关 键 词： | 血管性痴呆 学习记忆 突触后致密物95 |
| 文章编号： | 1006-351X（2007）04-0258-03 |
| 收稿时间： | 2007-04-02 |
| 修稿时间： | 2007-04-02 |
Study on expression of PSD-95 in hippocampus of mice with vascular dementia |
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| WANG Bing, WANG Pei, KANG Jun,et al.. Study on expression of PSD-95 in hippocampus of mice with vascular dementia[J]. Journal of Brain and Nervous Diseases, 2007, 15(4): 258-259,265 |
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| Authors: | WANG Bing WANG Pei KANG Jun et al. |
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| Affiliation: | Department of Neurology, the Third Hospital of Hebei Medical University, Shijiazhuang 050051 China |
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| Abstract: | Objective: To explore the changes of the expression of postsynaptic density 95 (PSD-95) in hippocampus of mice with vascular dementia (VD).Methods: The mice were subjected for ischemia reperfusion repeatly on bilateral common carotid arteries by knots to establish the VD models. The changes of behavior were observed through the step-down avoidance test and the expression of PSD-95 was observed by immunohistochemical method. Results: The abilities of the learning and memory of VD mice was impaired. The immunoreactivity of PSD-95 in hippocampal dentate gyrus(DG) decreased (P<0.05). Conclusion: The impairment of the abilities of learning and memory of VD mice might be related with the change of PSD-95 in hippocampus. |
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| Keywords: | Vascular dementia Learning and Memory Postsynaptic density 95 |
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