| Abstract: | The properties of the calcium pump of the sarcoplasmic reticulum (SR) from normal and denervated rabbit muscles were studied. The kinetics of transport of Ca++ ions in SR from denervated muscles obeys the Michaelis-Menten law. After denervation the rate of fast outflow of Ca++ from the vesicles is increased, leading to a decrease in the efficiency of transport and an increase in the activity of  basal ATPase. Meanwhile the rate of Ca++ accumulation and the activity of transport Ca-ATPase are increased by 1.5 times. The kinetic properties of the reticulum from denervated muscles correspond to the pattern of the contraction-relaxation cycle in those muscles.Department of Biochemistry, Biological Faculty, State University, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR S. E. Severin.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 81, No. 5, pp. 536–539, May, 1976 |
