Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells |
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| Authors: | Aoukaty Ala Lee I-Fang Wu John Tan Rusung |
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| Affiliation: | (1) Department of Pathology & Laboratory Medicine, British Columbia's Children's Hospital and University of British Columbia, Vancouver, British Columbia, Canada, V6H 3V4;(2) Department of Pediatrics, British Columbia's Children's Hospital and University of British Columbia, Vancouver, British Columbia, Canada, V6H 3V4 |
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| Abstract: | Chronic active Epstein–Barr virus (CAEBV) infection is an uncommon and severe manifestation of EBV infection that frequently leads to the development of natural killer (NK) or T cell lymphomas. We report here that NK cells derived from a boy with CAEBV showed decreased cytotoxic function and impaired interferon- secretion against a variety of transformed target cell lines. In addition, NK cells from the patient lacked expression of the broadly expressed NK receptor, leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1). These data suggest that CAEBV is associated with low expression of LAIR-1 on NK cells. |
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| Keywords: | Chronic active Epstein– Barr virus infection natural killer cells |
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