Detection of coronary artery disease with 13N-ammonia and high-resolution positron-emission computed tomography |
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| Authors: | Y Yonekura N Tamaki M Senda R Nohara H Kambara Y Konishi H Koide S A Kureshi H Saji T Ban |
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| Institution: | 1. Banner University Medical Center, University of Arizona, Tucson;2. Dow Medical University, Karachi City, Sindh, Pakistan;3. Mayo Clinic, Phoenix, Ariz;4. Mayo Clinic, Rochester, Minn;5. University of Arizona Cancer Center, Tucson;1. From Division of Endocrinology, Department of Medicine, John H Stroger Jr. Hospital of Cook County, Chicago, Illinois.;2. Department of Internal Medicine, John H Stroger Jr. Hospital of Cook County, Chicago, Illinois. |
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| Abstract: | In order to evaluate the detectability of coronary artery disease (CAD) with positron-emission computed tomography (PET), we performed 13N-ammonia myocardial PET scanning at rest and with exercise loading in 20 normal subjects and 40 patients with CAD, by means of a high-resolution, multi-slice, whole-body PET scanner. Myocardial PET scanning was performed 3 minutes after injection of 13N-ammonia at rest and during exercise. The circumferential profile analysis of resting PET images revealed regional hypoperfusion in 96% of CAD patients with previous myocardial infarction and in 29% of those without infarction. Exercise PET studies showed high sensitivity (93%) in detecting CAD without myocardial infarction, whereas no abnormal hypoperfusion was detected in normal subjects. Segmental analysis of regional myocardial perfusion with exercise stress identified 67 of 75 stenosed vessels (89%). We conclude that 13N-ammonia myocardial PET with exercise loading provides high-quality tomographic images of regional myocardial perfusion and is a valuable technique for detecting CAD. |
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