| 清胰化积方联合IL-2对胰腺癌小鼠脾淋巴细胞功能的影响 |
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| 引用本文： | 张剑军,陈震,刘鲁明,罗建民.清胰化积方联合IL-2对胰腺癌小鼠脾淋巴细胞功能的影响[J].中华中医药杂志,2009(2). |
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| 作者姓名： | 张剑军 陈震 刘鲁明 罗建民 |
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| 作者单位： | 复旦大学附属肿瘤医院;复旦大学上海医学院; |
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| 基金项目： | 上海市科委资助项目(No.02DZ19106) |
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| 摘 要： | 目的:研究清胰化积方联合白细胞介素-2(IL-2)对Panc02胰腺癌小鼠脾淋巴细胞功能的影响。方法:荷瘤小鼠随机分为对照组、清胰化积方组、清胰化积方联合不同剂量的IL-2组,治疗后称量瘤质量并计算抑瘤率,分别以淋巴细胞增殖活性和转化率评价小鼠脾淋巴细胞功能。结果:中药组、中药+IL-2小、中、大剂量组的瘤质量均小于对照组(P<0.01),抑瘤率分别为37.84%、44.14%、38.74%和39.64%;各治疗组脾淋巴细胞增殖活性和转化率均高于对照组(P<0.01),并呈现IL-2的剂量依赖性,其中中药+IL-2大剂量组最高,与中药组比较有显著性差异(P<0.05)。结论:增强脾淋巴细胞免疫功能是清胰化积方联合IL-2抗小鼠胰腺癌的机制之一;清胰化积方联合IL-2的免疫效应优于单用清胰化积方,具有协同效应。
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| 关 键 词： | 清胰化积方 胰腺癌 白细胞介素-2 脾淋巴细胞 |
Effect of Qingyi Huaji formula combined with IL-2 on immune function of splenic lymphocytes in mice with pancreatic cancer |
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| ZHANG Jian-jun,CHEN Zhen,LIU Lu-ming,LUO Jian-min.Effect of Qingyi Huaji formula combined with IL-2 on immune function of splenic lymphocytes in mice with pancreatic cancer[J].China Journal of Traditional Chinese Medicine and Pharmacy,2009(2). |
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| Authors: | ZHANG Jian-jun CHEN Zhen LIU Lu-ming LUO Jian-min |
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| Institution: | ZHANG Jian-jun1,2,CHEN Zhen1,LIU Lu-ming1,LUO Jian-min1(1Central laboratory of Cancer Hospital of Fudan University,Shanghai 200032,China,2Shanghai Medical College,Fudan University,China) |
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| Abstract: | Objective:To study the effect of Qingyi Huaji(QYHJ) formula combined with interleukin-2(IL-2) on immune function of splenic lymphocytes in mice bearing pancreatic cancer Panc02. Methods:Tumor-bearing mice were divided into control group,QYHJ group and groups of QYHJ combined with IL-2 at different dosages at random. After treatment,tumor weights were measured and tumor-inhibition rates were calculated,immune function of mice's splenic lymphocytes were evaluated by proliferation activity and transformation r... |
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| Keywords: | Qingyi Huaji formula Pancreatic cancer Interleukin-2 Splenic lymphocyte |
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