| 放射诱导鼠脑神经元凋亡 |
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| 摘 要： |
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| 关 键 词： | 鼠 脑神经元 照射剂量 X射线 神经元凋亡 |
Radiation-induced rat cerebral neuron apoptosis] |
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| Wen-feng Feng,Song-tao Qi,Bing-hui Qiu,Kai-jun Yang,Li-jing Huang. Radiation-induced rat cerebral neuron apoptosis][J]. Journal of First Military Medical University, 2004, 24(11): 1289-1291 |
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| Authors: | Wen-feng Feng Song-tao Qi Bing-hui Qiu Kai-jun Yang Li-jing Huang |
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| Affiliation: | Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. fengwf@fimmu.com |
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| Abstract: | OBJECTIVE: To explore the correlation between X-ray-induced rat cerebral neuron apoptosis and radiation doses. METHODS: In a controlled experiment, the rats in the experimental group received X-ray radiation at different doses (2, 4, 6 and 8 Gy), and the apoptotic cerebral neurons were counted after in situ end-labeling and immunohistochemical staining. RESULTS: X-ray radiation induced apoptosis of rat cerebral neurons, and the apoptotic rate varied with the radiation doses. Significant difference in the apoptotic rate was noted before and after radiation (P<0.0001), and between different radiation dose groups (P<0.005). The apoptotic rate differed significantly at different time points after the radiation. CONCLUSION: Low or medium doses of X-ray is able to induce rat cerebral neuron apoptosis depending on the radiation doses and following a definable time course. |
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