石斛及石斛合剂对糖尿病模型大鼠糖脂代谢的调整作用

为研究石斛及石斛合剂治疗糖尿病的机理，Wistar大鼠按体重分层随机法分为正常组和造模组，造模组按体重顺序编号，奇数鼠采用高脂高糖饲养1个月后腹腔注射低剂量的STZ造模，分别以优降糖、降糖灵治疗；偶数鼠用高脂高糖饲养1个月，先予石斛，石斛合剂低、中、高剂量分别灌胃2d后。以上法造模，再予石斛、石斛合剂治疗。1个月后测定各组动物糖脂代谢指标并行胰腺组织病理检查。结果：石斛及石斛合剂具有显著降低造模大鼠的血糖、三酰甘油、胆固醇、糖化血红蛋白，综合作用优于两西药对照组；低、中剂量石斛合剂提高胰岛素含量；石斛、高剂量石斛合剂增加外周组织胰岛素敏感性；石斛合剂各组可显著改善造模大鼠胰岛组织结构。结论：保护和修复胰岛组织结构，促进胰岛素分泌，增加外周组织对胰岛素的敏感性，可能是石斛及其制列治疗糖尿病的机理之一。

Effects of Dendrobium and Dendrobium Mixture on Lipid Metabolism in Diabetic Rats

To study the mechanism of Dendrobium and Dendrobium Mixture in the treatment of diabetes, Wistar rats were randomized into normal group and model group. The model group was subdivided into two subgroups according to the rats' weight: subgroup A in which the rats were fed high-lipid and high-sugar fodder for 1 month and then intraperitoneally given low-dosage STZ and finally treated by Glibenclamide and Phenformin, and subgroup B in which the rats were first fed high-lipid and high-sugar fodder for 1 month and then given low-dosage, moderate-dosage and high-dosage Dendrobium and Dendrobium Mixture for 2 months and finally modeled by STZ and treated by Dendrobium and Dendrobium Mixture. One month later, glucolipide metabolism and pancreatic pathology were detected. Results: Dendrobium and Dendrobium Mixture could decrease blood sugar, TG, cholesterol and saccharogenic hemoglobin, with significant differences compared with western medicines; low-dosage and moderate-dosage Dendrobium Mixture could increase the content of insulin; Dendrobium and high-dosage Dendrobium Mixture could increase the sensitivity of peripheral tissues to insulin; Dendrobium Mixture could obviously improve pancreatic structures. It is concluded that Dendrobium and its preparations can protect and recover pancreatic structures, increase the secretion of insulin and the sensitivity of peripheral tissues to insulin, eventually to treat diabetes.