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| 水飞蓟素固体脂质纳米粒体内药代动力学研究 | |
| 引用本文： | 何军,奉建芳,张乐乐,陆伟根,侯世祥.水飞蓟素固体脂质纳米粒体内药代动力学研究[J].中成药,2005,27(1):19-21. |
| 作者姓名： | 何军 奉建芳 张乐乐 陆伟根 侯世祥 |
| 作者单位： | 1. 上海医药工业研究院药物制剂部,上海,200437;四川大学华西药学院,四川,成都,610041 2. 上海医药工业研究院药物制剂部,上海,200437 3. 四川大学华西药学院,四川,成都,610041 |
| 基金项目： | 国家高技术研究发展计划(863计划)，上海市纳米科技专项基金 |
| 摘 要： | 目的:进行了水飞蓟素固体脂质纳米粒动物体内的生物利用度研究.方法:采用HPLC测定Beagle犬血浆中水飞蓟宾浓度,在选定的液相条件下,水飞蓟宾分离良好.结果:受试制剂和益肝灵片体内药动学均符合一室模型,水飞蓟素固体脂质纳米粒的相对生物利用度分别为258%.结论:水飞蓟素固体脂质纳米粒具有较高的生物利用度,固体脂质纳米粒是提高难溶性药物口服生物利用度的良好载体. |
| 关 键 词： | 水飞蓟素 固体脂质纳米粒 生物利用度 |
| 文章编号： | 1001-1528(2005)01-0019-03 |
Bioavailability of silymarin-loaded solid lipid nanoparticles |
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| HE Jun,FENG Jian-fang,ZHANG Le-le,LU Wei-gen,HOU Shi-xiang.Bioavailability of silymarin-loaded solid lipid nanoparticles[J].Chinese Traditional Patent Medicine,2005,27(1):19-21. | |
| Authors: | HE Jun FENG Jian-fang ZHANG Le-le LU Wei-gen HOU Shi-xiang |
| Abstract: | AIM: To study the oral bioavailability of silymarin-loaded solid lipid nanoparticles(SM-SLN). METHODS: Beagle dogs were employed as experiment animals, Yiganling Pian(Silymarin,SM) was used as the reference preparation. Silybin plasma concentration in rat was determined by RP-HPLC with UV detector. RESULTS: The pharmacokinetics of tested preparation and Yiganling Pian met with one-compartment, the relative bioavailability of SM-SLN was 258%(Yiganling Pian as reference). CONCLUSION: Results indicate that SM-SLN has better bioavailability than the reference preparation. It confirmes that SLN is one of good carrier for improving oral bioavailability of poorly-soluble drugs. |
| Keywords: | silymarin solid lipid nanoparticles bioavailability |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |