Tumor size as a prognostic factor in patients with stage IIa colon cancer |
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| Authors: | Francesco Santullo,Alberto Biondi,Ferdinando C.M. Cananzi,Valeria Fico,Flavio Tirelli,Riccardo Ricci,Gianluca Rizzo,Claudio Coco,Claudio Mattana,Domenico D&#x Ugo,Roberto Persiani |
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| Affiliation: | 1. General Surgery Unit, Department of Surgery, “A. Gemelli” University Hospital, Catholic University of Rome, Rome, Italy;2. Surgical Oncology Unit – Humanitas Clinical and Research Center, Rozzano, Italy;3. Department of Pathology, “A. Gemelli” University Hospital, Catholic University of Rome, Rome, Italy |
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| Abstract: | BackgroundThe aim of this study was to identify stage II colon cancer patients with a high risk of recurrence.MethodsAll patients who underwent surgery for stage II colon cancer (CC) were retrospectively enrolled and sub-grouped according to TNM staging (IIa-b-c) and stage IIa in high (IIaHR) and low risk (IIaLR) according to pathologic features.The primary outcomes measured were the 5-year overall survival (OS) and disease-free survival (DFS).ResultsA total of 214 patients were reviewed. Only a maximum tumor diameter<4 cm in the IIaLR group was associated with a higher recurrence rate than a large tumor size (5-year DFS 71.7%vs.87.6%, p = 0.028).The DFS in the large IIaLR CC group was better than that in the IIaHR and IIb-c groups (5-year DFS: 92.7%vs.79.3%, p = 0.023). In contrast, the recurrence rate in the small IIaLR CC group was similar to that in the IIaHR, IIb-c stage CC group.ConclusionsIn stage IIa CC evaluation of the tumor size as a prognostic factor may help identify patients who could benefit from additional postoperative therapy. |
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| Keywords: | Colorectal cancer Prognosis Stage II Adiuvant treatment Tumor size |
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