| 严重少精子症、无精子症15例的大Y遗传学分析 |
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| 引用本文： | 陈雪银,金应霞,李崎,麦扬青,黎明红. 严重少精子症、无精子症15例的大Y遗传学分析[J]. 海南医学院学报, 2006, 12(4): 314-316 |
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| 作者姓名： | 陈雪银 金应霞 李崎 麦扬青 黎明红 |
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| 作者单位： | 海南医学院附属医院妇产科、海南省生殖医学中心,海南,海口,570102 |
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| 摘 要： | 目的:探讨大Y与严重少精子症和无精子症的遗传学关系.方法:回顾性分析有实施单精子卵胞浆内注射意向的严重少精子症和无精子症患者为研究对象.进行染色体G带与Y染色体AZF区18个微缺失位点分析.结果:严重少精子症和无精子症患者病例共260例,其中大Y 15例(5.8%),但大Y中未发现AZF微缺失.结论:严重少精子症和无精子症中有部分患者为大Y,但没有发现大Y与Y染色体AZF微缺失相关.
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| 关 键 词： | 少精液症 Y染色体 染色体缺失 染色体异常 |
| 文章编号： | 1007-1237(2006)04-0314-03 |
| 收稿时间： | 2006-07-20 |
| 修稿时间： | 2006-07-20 |
A genetic study on long Y chromosome in 15 Cases of male with severe oligozoospermia and azoospermia |
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| Chen Xu-eyin, Jin Ying-xia, Li Qi,et al.. A genetic study on long Y chromosome in 15 Cases of male with severe oligozoospermia and azoospermia[J]. Journal of Hainan Medical College, 2006, 12(4): 314-316 |
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| Authors: | Chen Xu-eyin Jin Ying-xia Li Qi et al. |
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| Affiliation: | Chen Xu-eyin, Jin Ying-xia, Li Qi, et al. |
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| Abstract: | Objective: To investigate the genetic relation between longer Y chromosome and both severe oligozoospermia and azoospermia in male.Methods: Cytogenetic analysis of G band and 18 STS primers in the four regions of AZF were used for all the males with severe oligozoospermia and azoospermia,who wanted to put ICSI into practice.Results: 15 cases(5.8%) showed long Y chromosome in 260 cases male with severe oligozoospermia and azoospermia,but AZF microdeletions had not been founded.Conclusions: Some cases are long Y chromosome in male with severe oligozoospermia and azoospermia,but there is no correlation between long Y chromosome and AZF microdeletions. |
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| Keywords: | Oligozoospermia Long Y chromosome Chromosomal deficiency Chromosomal anomaly |
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