慢性肾功能不全患者血清及尿液超氧化物歧化酶含量的变化

用放射免疫分析测定７５例肾病患者血清和尿液含铜锌离子超氧化物歧化酶（Ｃｕ－Ｚｎ－Ｓｕｐｅｒｏｘｉｄｅｄｉｓｍｕｔａｓｅ，简称Ｃｕ－Ｚｎ－ＳＯＤ或ＳＯＤ－１）的含量，并与５１名健康人对比。结果显示，慢性肾功能不全（ＣＲＦ）血透组患者血清ＳＯＤ－１含量显著增高（Ｐ＜０．０１），随着血液透析期的延长，其含量有渐升趋势；非血透组略有降低（Ｐ＞０．０５；其它肾病组明显降低（Ｐ＜０．０１）。三组患者尿液ＳＯＤ－１含量呈不同程度增高（Ｐ均＜０．０１），并随着病变的严重程度而增幅更明显，血／尿ＳＯＤ－１比值也随之降低。本文初步分析了这些变化的原因及意义。

Changes of Serum and Urinary Superoxide Dismutase Concentration in Patients with Chronic Renal Failure

Serum and urinary SOD-1 (Cu-Zn-superoxide dismutase)concentrations in 75 patients with renal diseases were measured with radioimmunoassay. The results showed that serum SOD-1 in hemodialysis group (n=40) with chronic renal failure (CRF) was significantly higher than that of 51 normal persons (P<0.01),and there was a tendency to increase for SOD-1 with prolongation of hemodialysis period. Serum SOD-1 in non-hemodialysis group with CRF (n=13) was slightly decreased (P>0.05) and that of patients without CRF (n=23) was significantly lower than the normal level (P<0.01). Urinary SOD-1 contents were significantly higher in 3 groups of patients than in normal subjects (P<0.01) and there was a tendency to become more elevated for SOD-1 along with the sever ity of the disease so that serum-urinary SOD-1 ratio was simultaneously dropped. The implication of these changes is analysed in the report.