| 大黄有毒物质基础的研究 |
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| 引用本文： | 王建平. 大黄有毒物质基础的研究[J]. 中国民族民间医药杂志, 2011, 20(24): 63-64 |
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| 作者姓名： | 王建平 |
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| 作者单位： | 江苏省张家港市中医医院; |
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| 摘 要： | 目的：进行大黄体内有毒物质基础的研究。方法：以病理切片和血清生化为指标，对大黄总提取物组、大黄游离葸醌组、大黄结合蒽醌组、大黄总蒽醌组、大黄鞣质组和大黄多糖组进行小鼠体内毒性实验。结果：大黄各蒽醌组尤其是游离蒽醌组对小鼠主要毒性靶器官为肾脏，而鞣质部位则有潜在的肝毒性。结论：大黄中鞣质及蒽醌类成分有潜在肝肾毒性。
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| 关 键 词： | 大黄 蒽醌 鞣质 毒性 |
STUDY OF TOXIC SUBSTANSCE OF RHUBARB |
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| Wang Jianping Zhangjiagang City Hospital of Chinese Medicine,Zhangjiagang ,China. STUDY OF TOXIC SUBSTANSCE OF RHUBARB[J]. Chinese Journal of Ethnomedicine and Ethnopharmacy, 2011, 20(24): 63-64 |
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| Authors: | Wang Jianping Zhangjiagang City Hospital of Chinese Medicine Zhangjiagang China |
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| Affiliation: | Wang Jianping Zhangjiagang City Hospital of Chinese Medicine,Zhangjiagang 215600,China |
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| Abstract: | Objective: Identify the toxic substances of Rhubarb in vivo.Methods: According to the results of pathological section and serum biochemistry profiles of mice,study the effect of the total extract,the free anthraquinones,the bound anthraquinones,the total anthraquinones,tannin and polysaccharides in rhubarb.Results:The main toxic target organ of rhubarb is liver and kidney.Anthraquinones are its primary toxic substances,and tannin maybe the toxic substances which induce the liver toxicity.Conclusion:The tann... |
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| Keywords: | Rhubarb Anthraquinones Tannin Toxicity |
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