Enrofloxacin/florfenicol loaded cyclodextrin metal-organic-framework for drug delivery and controlled release |
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Authors: | Yucai Wei Chaoxi Chen Shuo Zhai Min Tan Juebo Zhao Xiaowen Zhu Lu Wang Qun Liu Tao Dai |
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Institution: | aCollege of Animal Science and Veterinary Medicine, Southwest Minzu University, Chengdu, China;bCollege of Chemistry & Environment, Southwest Minzu University, Chengdu, China |
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Abstract: | We presented an antibiotic-loaded γ-cyclodextrin metal-organic framework that delivered antibiotics suitable for the treatment of bacterial infections. The γ-cyclodextrin metal-organic framework was developed using γ-cyclodextrin and potassium ion via the ultrasonic method. The antibiotic (florfenicol and enrofloxacin) was primarily encapsulated into the pore structures of γ-CD-MOF, which allowed the sustained release of antibiotics over an extended period of time in vitro and in vivo. Notably, antibiotics-loaded γ-CD-MOF showed much superior activity against bacteria than free antibiotics (lower MIC value) and displayed better long-lasting activity (longer antibacterial time). The antibiotics-loaded γ-CD-MOF showed nontoxic and perfect biocompatibility to mammalian cells and tissues both in vitro and in vivo. These materials thus represent a novel drug-delivery device suitable for antibiotic therapy. This research is of great significance for reducing the generation of bacterial resistance and providing new ideas for the application of γ-CD-MOF. |
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Keywords: | γ -Cyclodextrin metal-organic framework antibacterial ability |
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