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神经型布鲁氏菌病的发病机制、诊断方法及预防
引用本文:赵婷婷,赵世刚,苏霄,刘丹. 神经型布鲁氏菌病的发病机制、诊断方法及预防[J]. 中国人兽共患病杂志, 2020, 36(6): 503-508. DOI: 10.3969/j.issn.1002-2694.2020.00.066
作者姓名:赵婷婷  赵世刚  苏霄  刘丹
作者单位:1. 内蒙古医科大学附属医院,呼和浩特 010050;2. 内蒙古医科大学附属医院,神经内科,呼和浩特 010050
基金项目:内蒙古自治区科技创新引导项目资助(No.KCBJ2018023)
摘    要:布鲁氏菌病是世界上分布最广的人兽共患病,也是世界卫生组织统计的7大最容易被忽视的疾病之一,是«中华人民共和国传染病防治法»规定的乙类传染病.由于管理不善和资源有限,特别是在发展中国家,近年来种内/种间(动物与动物之间/动物与人之间)感染率不断增加,至今仍困扰着世界.人类布鲁氏菌病易使多系统受累,一旦发展到慢性阶段,将难以治愈,对人类健康产生严重影响.神经系统受累为布鲁氏菌病的并发症之一,称为神经型布鲁氏菌病(neuobrucellosis,NB),NB在布鲁氏菌病中的发病率为1%~2%,本文重点总结了NB的发病机制、诊断方法及疫苗制作的研究进展,为今后该病在诊断及预防中提供线索.

关 键 词:神经型布鲁氏菌病  发病机制  诊断方法  疫苗研究
收稿时间:2019-07-15

Pathogenesis,diagnosis and prevention of neuropathic brucellosis
ZHAO Ting-ting,ZHAO Shi-gang,SU Xiao,LIU Dan. Pathogenesis,diagnosis and prevention of neuropathic brucellosis[J]. Chinese Journal of Zoonoses, 2020, 36(6): 503-508. DOI: 10.3969/j.issn.1002-2694.2020.00.066
Authors:ZHAO Ting-ting  ZHAO Shi-gang  SU Xiao  LIU Dan
Affiliation:1. Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050,China;2. Department of Neurology,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China
Abstract:Brucellosis is the most widely distributed zoonotic disease in the world. It is also one of the seven most easily overlooked diseases counted by the World Health Organization. It is a Class B infection prescribed by the People’s Republic of China on the prevention and control of infectious diseases. Due to poor management and limited resources, especially in developing countries, the rate of intra-and inter-species(between animals and animals/animal-to-human) infection has increased greatly in recent years, and it still plagues the world. Human brucellosis is easy to involve multiple systems. Once it develops to a chronic stage, brucellosis will be difficult to cure and has a serious impact on human health. The nervous system is involved in one of the complications of brucellosis, called neuroobrucellosis (NB), and the incidence of NB in brucellosis is 1% to 2%. It is estimated that at all in brucellosis, up to 25% of cases have neurological symptoms. This review focuses on the research progress of NB pathogenesis, diagnostic methods and vaccine production, and provides clues for the diagnosis and prevention of this disease in the future.
Keywords:neuroobrucellosis  pathogenesis  diagnostic method  vaccine research  
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