颈动脉血管重建术对颈动脉狭窄患者认知功能的影响

颈动脉狭窄会导致患者远期认知功能下降，而既往研究表明颈动脉内膜剥脱术和支架置入术作为治疗颈动脉狭窄的主要术式，可以改善患者的认知功能，尤其是执行能力等特定领域的认知水平。进一步研究发现颈动脉血管重建术中栓子的形成，术后脑血流灌注提高，以及神经代谢水平等改变可能在机制上解释颈动脉重建术后认知功能的变化；此外，围术期炎症反应，血脂水平，以及基因易感性等都是术后远期认知功能结局的临床预测因素，以上因素对于提高颈动脉狭窄患者的生活质量、治疗术式的优化具有重要临床意义。

Effects of Carotid Revascularization on Cognitive Function in Patients with Carotid Stenosis

Carotid stenosis can lead to long-term cognitive function decline. Carotidendarterectomy and carotid artery stenting, two major procedures for carotid stenosis, have beenproven to improve the cognitive function, especially for executive domain. Further studies foundthat the formation of emboli during the operation, the increase of cerebral blood flow perfusionand the change of neurometabolism might account for the changes in cognitive function aftercarotid revascularization. In addition, perioperative inflammatory response, lipid level and genesusceptibility may be predictors of long-term cognitive prognosis, and all the above factors areof great clinical significance for improving the life quality of patients with carotid stenosis andoptimizing the procedures.