卒中后抑郁脑网络的研究进展

卒中后抑郁(post-stroke depression,PSD)是卒中后最常见的精神并发症,有近三分之一的卒中幸存者会罹患PSD。目前越来越多的证据支持脑网络的异常改变是导致PSD的神经生理病理基础。卒中局部病变不仅导致特定局部脑网络(情感网络、默认网络、突显网络、记忆控制网络等)发生重构,而且还可引发全脑脑网络拓扑结构的重塑。部分卒中患者在脑网络重塑过程中,情感相关的网络发生了特征性重构,最终导致脑功能的失常出现了临床抑郁症状,导致PSD的发生。本文就PSD的脑网络研究的最新进展进行综述,以探讨PSD的发病机制。

Emergency Thrombectomy for Acute Ischemic Stroke under the COVID-19 Epidemic

Post-stroke depression (PSD) is the most common psychiatric complication after stroke, affecting nearly a third of stroke survivors. Emerging evidence supported that abnormal changes in brain networks are the neurophysiological basis of PSD. The focal brain lesions can not only result in the remodeling of some specific brain networks (such as affective network, default mood network, salience network, cognitive control network), but also the topological reorganization of the whole brain networks. During the remodeling of brain networks in some stroke patients, the abnormal changes of affective network can lead to partial brain dysfunction, and depression symptoms occurr, that’s PSD. In order to explore the pathogenesis of PSD, this article reviewed the latest research on brain networks in PSD.