Serum neutrophil gelatinase-associated lipocalin concentrations are significantly associated with the severity of COVID-19 in pregnant patients |
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Authors: | Esra Can Süleyman Cemil Olak Fatma
lmez Huri Bulut |
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Institution: | From the Department of Obstetrics and Gynecology (Can, Ölmez), Health Sciences University, Kanuni Sultan Süleyman Training and Research Hospital, from the Department of Medical Biochemistry (Bulut), School of Medicine, Istinye University, Istanbul, and from the Department of Obstetrics and Gynecology (Oğlak), Health Sciences University, Gazi Yaşargil Training and Research Hospital, Diyarbakır, Turkey. |
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Abstract: | Objectives:To evaluate serum neutrophil gelatinase-associated lipocalin (NGAL) concentrations of pregnant women complicated with coronavirus disease 2019 (COVID-19) and investigate its diagnostic value for the severity of COVID-19.Methods:Of the 46 pregnant women with COVID-19 included in the study, we further classified these women into 2 subgroups: the non-severe COVID-19 group (n=25) and the severe COVID-19 group (n=21).Results:Neutrophil gelatinase-associated lipocalin plasma concentrations were significantly higher in pregnant women complicated with severe COVID-19 (90 53.1-207.7] ng/ml) compared to those from pregnant women with non-severe COVID-19 (51.8 39.6-70.3] ng/ml) and healthy pregnant women (44.3 32.2-54.1] ng/ml, p<0.001). Also, at a cutoff value of 72 ng/ml, NGAL predicted severe COVID-19 with a sensitivity rate of 57% and a specificity rate of 84%. Serum NGAL level (adjusted hazard ratio aHR]=1.020, 95% confidence interval CI]= 1.006-1.035], p=0.007), and D-dimer level (aHR=2.371, 95% CI= 1.085-5.181], p=0.030) were the variables that were revealed to be significantly associated with the disease severity.Conclusion:We demonstrated that NGAL was highly associated with COVID-19 severity. We consider that NGAL might be a useful biomarker to diagnose the disease severity in patients with COVID-19. |
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Keywords: | COVID-19 disease severity neutrophil gelatinase-associated lipocalin |
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