A new abietane diterpenoid from Isodon inflexus |
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| Authors: | Chul Lee Seong Su Hong Xiang Hua Han Qinghao Jin Dayu Li Tae Ook Kim Hyun-Kyu Kim Jeongrai Lee Suk Hyung Kwon Yun-Bae Kim Mi Kyeong Lee Bang Yeon Hwang |
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| Affiliation: | (1) College of Pharmacy, Chungbuk National University, Cheongju, 361-763, Korea;(2) Rexgene Biotech Co., Ltd., Ochang, Cheongwon, Chungbuk, 363-883, Korea;(3) College of Veterinary Medicine, Chungbuk National University, Cheongju, 361-763, Korea |
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| Abstract: | A new ent-abietane diterpenoid, 3α,6β-dihydroxy-7,17-dioxo-ent-abieta-15(16)-ene (1), and three known ent-kaurane diterpenids, kamebacetal A (2), kamebakaurin (3), and excisanin A (4), and a known triterpenoid, ursolic acid (5), were isolated from the aerial parts of Isodon inflexus. Their chemical structures were determined by extensive analysis of spectroscopic data including 1D-and 2D-NMR experiments. All isolates (1–5) were evaluated for their potential to inhibit LPS-induced nitric oxide production in RAW264.7 cells. Of these, compounds 1–4 inhibited the production of NO with IC50 values ranging from 1.0 to 26.5 μM. |
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| Keywords: | Isodon inflexus Lamiaceae ent-Abietane Nitric oxide production inhibitor |
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