血清NSE对小细胞肺癌的诊断价值

Ginical Significance of Serum Neuron Specific Enolase in Small Cell Carcinoma of me Lung

The serum neuron specific enolase (NSE), lipid-pound sialic add (LSA) and carcinoembryonic antigen (CEA) levels were measured in 58 normal controls, 17 patients with benign pulmonary diseases (BPD), 16 patients with small cell lung cancer (SCLQ and 29 patients with non-SCLC. The results showed that serum NSE level was markedly elevated in patients with SCLC compared to non-SCLC and BPD. NSE levels at diagnosis tended to correlate with the initial tumor burden as evidenced by increasing mean NSE value be ing associated with increasing number of metastatic sites. Thirteen out of sixteen SCLC patients had NSE level raised but only six had LSA raised (sensitivity 37.5%) and three CEA raised (sensitivity 18.8%). Our study indicated that NSE was more helpful than LSA, CEA for diagnosis and differential diagnosis of SCLC and evaluating status of the disease. The incidence of at least 1 elevated marker increased from 81.3% using NSE alone to 93.8% using NSE, LSA and CEA together.