The Presence of CA19-9 in Serum and Saliva from Lewis Blood-group Negative Cancer Patients期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

The Presence of CA19-9 in Serum and Saliva from Lewis Blood-group Negative Cancer Patients

Authors:	Shin Yazawa Takayuki Asao Hideaki Izawa Yukio Miyamoto Khushi L. Matta

Affiliation:	Department of Legal Medicine, School of Medicine, Gunma University, 3-39-22, Showa-machi, Maebashi 371;Gunma Cancer Center, Ohta 373, Roswell Park Memorial Institute, Buffalo, New York 14263, USA;Second Department of Surgery, School of Medicine, Gunma University, 3-39-22, Showa-machi, Maebashi 371;Department of Gynecologic Oncology, Roswell Park Memorial Institute, Buffalo, New York 14263, USA

Abstract:	Eighteen cancer patients showed high levels of CA19-9 in sera, even though the blood-group phenotypes of their red blood cells were Le(a — b —). Seven of these patients (group I) were determined as Le(a — b —) from both red blood cells and saliva consistently, whereas eleven other patients (group II) secreted either Le^a or Le^b antigen in saliva and showed the expression of incompatible Lewis blood-group antigens. GDP-fucose: N -acetyl-glucosaminide a (1 × 4)-L-fucosyltransferase was demonstrated to be present in salivas from both group I and group II. These results suggest that a cancer-associated alteration of Lewis blood-group antigen expression occurs in cancer patients.

Keywords:	CA19-9 Lewis blood groups Salivary a(1→4)-L-fucosyltransferase Incompatible expression of blood-groups