Successful cardiac preservation for 12 hours using nondepolarizing cold cardioplegia. A canine model |
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Authors: | Makoto Sunamori Hisashi Miyamoto Tetsuya Yoshida Akio Suzuki |
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Institution: | Department of Thoracic-Cardiovascular Surgery, Tokyo Medical and Dental University, School of Medicine, 1–5-45, Yushima, Bunkyo-ku, Tokyo, 113, Japan |
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Abstract: | Abstract Isolated canine hearts were preserved for 12 h at 5 °C followed by normothermic reperfusion for 2 h. Dogs were divided into two groups: group 1 ( n = 7) received a nondepolarizing preservation solution in multidose, and group 2 ( n = 6) received single-flushed University of Wisconsin (UW) solution, both administered in multidose fashion. At the end o reperfusion, the myocardial adenosine triphosphate concentration and left ventricular systolic and diastolic function were preserved better in group 1 than in group 2. Myocardial mitochondrial ultra-tructural integrity was identical in the two groups. These results suggested that in a 124 heart preservation, nondepolarizing solution administered in multidose fashion protects the myocardium from the deleterious effects of hypothermia and cardioplegia better than UW solution. |
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Keywords: | Depolarization Multidose cardioplegia Myocardial preservation Hypothermia UW solution Adenine nucleotide |
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