有无遗传史的强迫症患者前额叶磁共振质子波谱对照研究

目的 探讨有无遗传史强迫症患者前额叶神经代谢物的变化.方法 采用磁共振质子波谱技术对有遗传史强迫症组(10例)、无遗传史强迫症组(14例)和对照组(12例)的内侧前额叶皮质N-乙酰天冬氨酸(NAA)、肌酸(Cr)和胆碱复合物(Cho)的代谢物含量进行对照研究.结果 有遗传史强迫症组的NAA值(46±8)和NAA/Cr值(1.59±0.24)分别高于对照组的NAA值(37±7)(方差分析LSD法校正,P=0.024)和NAA/Cr值(1.31±0. 21)(方差分析LSD法校正,P=0.006);有遗传史强迫症组的NAA值也高于无遗传史强迫症组的NAA值(37±10)(方差分析LSD法校正,P=0.021);无遗传史强迫症组与对照组相比,NAA/Cr值可见增加趋势(方差分析LSD法校正,P=0.066).结论 有遗传史强迫症患者的神经代谢物NAA与对照组和无遗传史强迫症患者相比在内侧前额叶皮质明显升高.

A proton magnetic resonance spectroscopy study of prefrontal cortex in obsessive-compulsive disorder patients with and without inherited history

Objective To explore the neurochemical changes in the prefrontal cortex among obsessive-compulsive disorder (OCD) patients with and without inherited history. Methods The N-acetylaspartate (NAA), creatine (Cr) and choline-containing compound (Cho) levels in the medial prefrontal cortex using proton magnetic resonance spectroscopy (1H-MRS) were compared among 10 OCD patients with inherited history and 14 OCD patients without inherited history and 12 healthy controls. Results The NAA level (46 ±8) and NAA/Cr level ( 1.59 ±0. 24) in the OCD patients with inherited history were higher than that NAA (37 ±7) and NAA/Cr ( 1.31 ±0. 21) in the healthy controls. The NAA level in the OCD patients with inherited history was also higher than that in the OCD patients without inherited history.The increasing tendency of the NAA/Cr level was found in the OCD patients without inherited history as compared to the healthy controls. Conclusions The increases of neurochemical metabolite NAA levels in the medial prefrontal cortex may be higher in OCD patients with inherited history as compared to healthy controls and OCD patients without inherited history.